Alzheimer's disease risk factor complement receptor 1 is associated with depression

Gillian Hamilton; Kathryn Evans; Donald J MacIntyre; Ian Deary; A. Dominiczak; Blair H. Smith; Andrew Morris; David Porteous; Pippa Thomson

doi:10.1016/j.neulet.2011.12.059

Alzheimer's disease risk factor complement receptor 1 is associated with depression

Gillian Hamilton, Kathryn Evans, Donald J MacIntyre, Ian Deary, A. Dominiczak, Blair H. Smith, Andrew Morris, David Porteous, Pippa Thomson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.

Original language	English
Pages (from-to)	6-9
Number of pages	4
Journal	Neuroscience Letters
Volume	510
Issue number	1
Early online date	8 Jan 2012
DOIs	https://doi.org/10.1016/j.neulet.2011.12.059
Publication status	Published - 21 Feb 2012

Keywords / Materials (for Non-textual outputs)

Association study
Major recurrent depression
Complement receptor 1
Alzheimer's disease

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10.1016/j.neulet.2011.12.059

http://www.sciencedirect.com/science/article/pii/S0304394012000043

Cite this

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title = "Alzheimer's disease risk factor complement receptor 1 is associated with depression",

abstract = "Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.",

keywords = "Association study , Major recurrent depression , Complement receptor 1 , Alzheimer's disease ",

author = "Gillian Hamilton and Kathryn Evans and MacIntyre, {Donald J} and Ian Deary and A. Dominiczak and Smith, {Blair H.} and Andrew Morris and David Porteous and Pippa Thomson",

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AU - Hamilton, Gillian

AU - Evans, Kathryn

AU - MacIntyre, Donald J

AU - Deary, Ian

AU - Dominiczak, A.

AU - Smith, Blair H.

AU - Morris, Andrew

AU - Porteous, David

AU - Thomson, Pippa

PY - 2012/2/21

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N2 - Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.

AB - Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.

KW - Association study

KW - Major recurrent depression

KW - Complement receptor 1

KW - Alzheimer's disease

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DO - 10.1016/j.neulet.2011.12.059

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Alzheimer's disease risk factor complement receptor 1 is associated with depression

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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