Amide bond formation: beyond the myth of coupling reagents

Eric Valeur; Mark Bradley

doi:10.1039/b701677h

Amide bond formation: beyond the myth of coupling reagents

Eric Valeur, Mark Bradley

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym'' based reagents. It aims to demystify the process allowing the chemist to make a sensible and educated choice when carrying out an amide coupling reaction (179 references).

Original language	English
Pages (from-to)	606-631
Number of pages	26
Journal	Chemical Society Reviews
Volume	38
Issue number	2
DOIs	https://doi.org/10.1039/b701677h
Publication status	Published - 2009

Keywords / Materials (for Non-textual outputs)

PHASE PEPTIDE-SYNTHESIS
BENZOTRIAZOL-1-YL DIETHYL PHOSPHATE
N-HYDROXYSUCCINIMIDE ESTERS
SUPPORTED MUKAIYAMA REAGENT
METHYLATED AMINO-ACIDS
MIXED ANHYDRIDE METHOD
CHLORIDE BOP-CL
SOLID-PHASE
HIGHLY EFFICIENT
DIPHENYL PHOSPHATE

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10.1039/b701677h

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title = "Amide bond formation: beyond the myth of coupling reagents",

abstract = "Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of {"}acronym'' based reagents. It aims to demystify the process allowing the chemist to make a sensible and educated choice when carrying out an amide coupling reaction (179 references).",

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author = "Eric Valeur and Mark Bradley",

year = "2009",

doi = "10.1039/b701677h",

language = "English",

volume = "38",

pages = "606--631",

journal = "Chemical Society Reviews",

issn = "0306-0012",

publisher = "Royal Society of Chemistry",

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T1 - Amide bond formation: beyond the myth of coupling reagents

AU - Valeur, Eric

AU - Bradley, Mark

PY - 2009

Y1 - 2009

N2 - Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym'' based reagents. It aims to demystify the process allowing the chemist to make a sensible and educated choice when carrying out an amide coupling reaction (179 references).

AB - Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym'' based reagents. It aims to demystify the process allowing the chemist to make a sensible and educated choice when carrying out an amide coupling reaction (179 references).

KW - PHASE PEPTIDE-SYNTHESIS

KW - BENZOTRIAZOL-1-YL DIETHYL PHOSPHATE

KW - N-HYDROXYSUCCINIMIDE ESTERS

KW - SUPPORTED MUKAIYAMA REAGENT

KW - METHYLATED AMINO-ACIDS

KW - MIXED ANHYDRIDE METHOD

KW - CHLORIDE BOP-CL

KW - SOLID-PHASE

KW - HIGHLY EFFICIENT

KW - DIPHENYL PHOSPHATE

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U2 - 10.1039/b701677h

DO - 10.1039/b701677h

M3 - Literature review

SN - 0306-0012

VL - 38

SP - 606

EP - 631

JO - Chemical Society Reviews

JF - Chemical Society Reviews

IS - 2

ER -

Amide bond formation: beyond the myth of coupling reagents

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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