AMPA receptors in the synapse: Very little space and even less time

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Glutamate is by far the most abundant neurotransmitter used by excitatory synapses in the vertebrate central nervous system. Once released into the synaptic cleft, it depolarises the postsynaptic membrane and activates downstream signalling pathways resulting in the propagation of the excitatory signal. Initial depolarisation is primarily mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. These ion channels are the first ones to be activated by released glutamate and their kinetics, dynamics and abundance on the postsynaptic membrane defines the strength of the postsynaptic response. This review focuses on native AMPA receptors and synaptic environment they inhabit and considers structural and functional properties of the receptor obtained in heterologous systems in the light of spatial and temporal constrains of the synapse.
Original languageEnglish
Article number108711
Number of pages24
JournalNeuropharmacology
Volume196
Early online date13 Jul 2021
DOIs
Publication statusPublished - 15 Sep 2021

Keywords

  • AMPA receptors
  • synapse
  • synaptic dimensions
  • presynaptic proteins
  • postsynaptic proteins

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