Original language | English |
---|---|
Journal | Nature Communications |
Early online date | 26 Aug 2022 |
DOIs | |
Publication status | E-pub ahead of print - 26 Aug 2022 |
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In: Nature Communications, 26.08.2022.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death
AU - Moral-Sanz, Javier
AU - Lewis, Sophronia
AU - Macmillan, Sandy
AU - Meloni, Marco
AU - McClafferty, Heather
AU - Viollet, Benoit
AU - Foretz, Marc
AU - Del-Pozo, Jorge
AU - Evans, A Mark
N1 - Funding Information: First and foremost, Mark Evans would like to acknowledge the late Professor Sheila Glennis Haworth CBE who, during a chance meeting at PVRI 2019, confirmed his conclusion that the pathology described here was most consistent with PPHN, gave further guidance and re-introduced him to Dr Alison Hislop, who all authors thank for her kind consideration and further guidance. We thank Brendan Corcoran for introducing Jorge del Pozo to the Evans Laboratory, without whose kind support and histological expertise we could not have been completed this study. Thanks also to Dr Fiona A. Ross, Professor D. Grahame Hardie and Dr Mark L. Dallas for experimental support. Finally, all authors would like to thank members of the University of Edinburgh Bioresearch and Veterinary Services (BVS) who stepped above and beyond their normal duties to help us achieve our aims by facilitating studies on neonatal mice, namely Matt Sharp, Neil Odey, Peter Rutherford and Iain McCall. This work was funded by programme grants awarded to AME from the Wellcome Trust (WT081195MA, which funded S.L.) and the British Heart Foundation (RG/12/14/29885, which funded J.M.S., S.L. and H.M.). Additional support was provided by Professor Michael J. Shipston, Dean of Biomedical Sciences, University of Edinburgh. Funding Information: First and foremost, Mark Evans would like to acknowledge the late Professor Sheila Glennis Haworth CBE who, during a chance meeting at PVRI 2019, confirmed his conclusion that the pathology described here was most consistent with PPHN, gave further guidance and re-introduced him to Dr Alison Hislop, who all authors thank for her kind consideration and further guidance. We thank Brendan Corcoran for introducing Jorge del Pozo to the Evans Laboratory, without whose kind support and histological expertise we could not have been completed this study. Thanks also to Dr Fiona A. Ross, Professor D. Grahame Hardie and Dr Mark L. Dallas for experimental support. Finally, all authors would like to thank members of the University of Edinburgh Bioresearch and Veterinary Services (BVS) who stepped above and beyond their normal duties to help us achieve our aims by facilitating studies on neonatal mice, namely Matt Sharp, Neil Odey, Peter Rutherford and Iain McCall. This work was funded by programme grants awarded to AME from the Wellcome Trust (WT081195MA, which funded S.L.) and the British Heart Foundation (RG/12/14/29885, which funded J.M.S., S.L. and H.M.). Additional support was provided by Professor Michael J. Shipston, Dean of Biomedical Sciences, University of Edinburgh. Publisher Copyright: © 2022, The Author(s).
PY - 2022/8/26
Y1 - 2022/8/26
U2 - 10.1038/s41467-022-32568-7
DO - 10.1038/s41467-022-32568-7
M3 - Article
SN - 2041-1723
JO - Nature Communications
JF - Nature Communications
ER -