An allelic association study of two polymorphic markers in close proximity to a balanced translocation t(1:11) that co-segregates with mental illness

J C Wilson-Annan, Douglas Blackwood, W Muir, Kirsty Millar, D J Porteous

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case control association study using polymorphic markers D1S1621 and D11S931 in unrelated individuals with schizophrenia, unipolar depression and a matched control group. The two polymorphic markers were identified during the positional cloning of the translocation breakpoint t(1:11)(q43:q14.3) that cosegregates with schizophrenia and affective disorders. These markers provided an opportunity to investigate linkage disequilibrium with a postulated schizophrenia susceptibility gene close to the translocation breakpoint in random populations of schizophrenia and unipolar depression individuals compared with a normal control population. No significant differences between allele frequencies for either of the markers in the affected populations were observed in comparison with the control group, which provides evidence against a nearby gene of major effect in the populations studied.
Original languageEnglish
Pages (from-to)171-4
Number of pages4
JournalPsychiatric Genetics
Volume7
Issue number4
Publication statusPublished - 1997

Keywords

  • Alleles
  • Case-Control Studies
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 11
  • Data Interpretation, Statistical
  • Depression
  • Gene Frequency
  • Genetic Linkage
  • Genetic Markers
  • Genotype
  • Humans
  • Mental Disorders
  • Polymorphism, Genetic
  • Schizophrenia
  • Translocation, Genetic

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