An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype

Nese Direk; Stephanie Williams; Jennifer A. Smith; Stephan Ripke; Tracy Air; Azmeraw T. Amare; Najaf Amin; Bernhard T. Baune; David A. Bennett; Douglas H.r. Blackwood; Dorret Boomsma; Gerome Breen; Henriette N. Buttenschøn; Enda M. Byrne; Anders D. Børglum; Enrique Castelao; Sven Cichon; Toni-kim Clarke; Marilyn C. Cornelis; Udo Dannlowski; Philip L. De Jager; Ayse Demirkan; Enrico Domenici; Cornelia M. Van Duijn; Erin C. Dunn; Johan G. Eriksson; Tonu Esko; Jessica D. Faul; Luigi Ferrucci; Myriam Fornage; Eco De Geus; Michael Gill; Scott D. Gordon; Hans Jörgen Grabe; Gerard Van Grootheest; Steven P. Hamilton; Catharina A. Hartman; Andrew C. Heath; Karin Hek; Albert Hofman; Georg Homuth; Carsten Horn; Jouke Jan Hottenga; Sharon L.r. Kardia; Stefan Kloiber; Karestan Koenen; Zoltán Kutalik; Karl-heinz Ladwig; Jari Lahti; Douglas F. Levinson; Cathryn M. Lewis; Glyn Lewis; Qingqin S. Li; David J. Llewellyn; Susanne Lucae; Kathryn L. Lunetta; Donald J. Macintyre; Pamela Madden; Nicholas G. Martin; Andrew M. Mcintosh; Andres Metspalu; Yuri Milaneschi; Grant W. Montgomery; Ole Mors; Thomas H. Mosley; Joanne M. Murabito; Bertram Müller-myhsok; Markus M. Nöthen; Dale R. Nyholt; Michael C. O’donovan; Brenda W. Penninx; Michele L. Pergadia; Roy Perlis; James B. Potash; Martin Preisig; Shaun M. Purcell; Jorge A. Quiroz; Katri Räikkönen; John P. Rice; Marcella Rietschel; Margarita Rivera; Thomas G. Schulze; Jianxin Shi; Stanley Shyn; Grant C. Sinnamon; Johannes H. Smit; Jordan W. Smoller; Harold Snieder; Toshiko Tanaka; Katherine E. Tansey; Alexander Teumer; Rudolf Uher; Daniel Umbricht; Sandra Van Der Auwera; Erin B. Ware; David R. Weir; Myrna M. Weissman; Gonneke Willemsen; Jingyun Yang; Wei Zhao; Henning Tiemeier; Patrick F. Sullivan

doi:10.1016/j.biopsych.2016.11.013

An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype

Nese Direk, Stephanie Williams, Jennifer A. Smith, Stephan Ripke, Tracy Air, Azmeraw T. Amare, Najaf Amin, Bernhard T. Baune, David A. Bennett, Douglas H.r. Blackwood, Dorret Boomsma, Gerome Breen, Henriette N. Buttenschøn, Enda M. Byrne, Anders D. Børglum, Enrique Castelao, Sven Cichon, Toni-kim Clarke, Marilyn C. Cornelis, Udo DannlowskiPhilip L. De Jager, Ayse Demirkan, Enrico Domenici, Cornelia M. Van Duijn, Erin C. Dunn, Johan G. Eriksson, Tonu Esko, Jessica D. Faul, Luigi Ferrucci, Myriam Fornage, Eco De Geus, Michael Gill, Scott D. Gordon, Hans Jörgen Grabe, Gerard Van Grootheest, Steven P. Hamilton, Catharina A. Hartman, Andrew C. Heath, Karin Hek, Albert Hofman, Georg Homuth, Carsten Horn, Jouke Jan Hottenga, Sharon L.r. Kardia, Stefan Kloiber, Karestan Koenen, Zoltán Kutalik, Karl-heinz Ladwig, Jari Lahti, Douglas F. Levinson, Cathryn M. Lewis, Glyn Lewis, Qingqin S. Li, David J. Llewellyn, Susanne Lucae, Kathryn L. Lunetta, Donald J. Macintyre, Pamela Madden, Nicholas G. Martin, Andrew M. Mcintosh, Andres Metspalu, Yuri Milaneschi, Grant W. Montgomery, Ole Mors, Thomas H. Mosley, Joanne M. Murabito, Bertram Müller-myhsok, Markus M. Nöthen, Dale R. Nyholt, Michael C. O’donovan, Brenda W. Penninx, Michele L. Pergadia, Roy Perlis, James B. Potash, Martin Preisig, Shaun M. Purcell, Jorge A. Quiroz, Katri Räikkönen, John P. Rice, Marcella Rietschel, Margarita Rivera, Thomas G. Schulze, Jianxin Shi, Stanley Shyn, Grant C. Sinnamon, Johannes H. Smit, Jordan W. Smoller, Harold Snieder, Toshiko Tanaka, Katherine E. Tansey, Alexander Teumer, Rudolf Uher, Daniel Umbricht, Sandra Van Der Auwera, Erin B. Ware, David R. Weir, Myrna M. Weissman, Gonneke Willemsen, Jingyun Yang, Wei Zhao, Henning Tiemeier, Patrick F. Sullivan

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Biological Psychiatry
Early online date	8 Dec 2016
DOIs	https://doi.org/10.1016/j.biopsych.2016.11.013
Publication status	E-pub ahead of print - 8 Dec 2016

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Direk, N., Williams, S., Smith, J. A., Ripke, S., Air, T., Amare, A. T., Amin, N., Baune, B. T., Bennett, D. A., Blackwood, D. H. R., Boomsma, D., Breen, G., Buttenschøn, H. N., Byrne, E. M., Børglum, A. D., Castelao, E., Cichon, S., Clarke, T., Cornelis, M. C., ... Sullivan, P. F. (2016). An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2016.11.013

Direk, Nese ; Williams, Stephanie ; Smith, Jennifer A. ; Ripke, Stephan ; Air, Tracy ; Amare, Azmeraw T. ; Amin, Najaf ; Baune, Bernhard T. ; Bennett, David A. ; Blackwood, Douglas H.r. ; Boomsma, Dorret ; Breen, Gerome ; Buttenschøn, Henriette N. ; Byrne, Enda M. ; Børglum, Anders D. ; Castelao, Enrique ; Cichon, Sven ; Clarke, Toni-kim ; Cornelis, Marilyn C. ; Dannlowski, Udo ; De Jager, Philip L. ; Demirkan, Ayse ; Domenici, Enrico ; Van Duijn, Cornelia M. ; Dunn, Erin C. ; Eriksson, Johan G. ; Esko, Tonu ; Faul, Jessica D. ; Ferrucci, Luigi ; Fornage, Myriam ; Geus, Eco De ; Gill, Michael ; Gordon, Scott D. ; Grabe, Hans Jörgen ; Grootheest, Gerard Van ; Hamilton, Steven P. ; Hartman, Catharina A. ; Heath, Andrew C. ; Hek, Karin ; Hofman, Albert ; Homuth, Georg ; Horn, Carsten ; Hottenga, Jouke Jan ; Kardia, Sharon L.r. ; Kloiber, Stefan ; Koenen, Karestan ; Kutalik, Zoltán ; Ladwig, Karl-heinz ; Lahti, Jari ; Levinson, Douglas F. ; Lewis, Cathryn M. ; Lewis, Glyn ; Li, Qingqin S. ; Llewellyn, David J. ; Lucae, Susanne ; Lunetta, Kathryn L. ; Macintyre, Donald J. ; Madden, Pamela ; Martin, Nicholas G. ; Mcintosh, Andrew M. ; Metspalu, Andres ; Milaneschi, Yuri ; Montgomery, Grant W. ; Mors, Ole ; Mosley, Thomas H. ; Murabito, Joanne M. ; Müller-myhsok, Bertram ; Nöthen, Markus M. ; Nyholt, Dale R. ; O’donovan, Michael C. ; Penninx, Brenda W. ; Pergadia, Michele L. ; Perlis, Roy ; Potash, James B. ; Preisig, Martin ; Purcell, Shaun M. ; Quiroz, Jorge A. ; Räikkönen, Katri ; Rice, John P. ; Rietschel, Marcella ; Rivera, Margarita ; Schulze, Thomas G. ; Shi, Jianxin ; Shyn, Stanley ; Sinnamon, Grant C. ; Smit, Johannes H. ; Smoller, Jordan W. ; Snieder, Harold ; Tanaka, Toshiko ; Tansey, Katherine E. ; Teumer, Alexander ; Uher, Rudolf ; Umbricht, Daniel ; Der Auwera, Sandra Van ; Ware, Erin B. ; Weir, David R. ; Weissman, Myrna M. ; Willemsen, Gonneke ; Yang, Jingyun ; Zhao, Wei ; Tiemeier, Henning ; Sullivan, Patrick F. / An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype. In: Biological Psychiatry. 2016.

@article{e834d00267894b068c1c95efd9555017,

title = "An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype",

author = "Nese Direk and Stephanie Williams and Smith, {Jennifer A.} and Stephan Ripke and Tracy Air and Amare, {Azmeraw T.} and Najaf Amin and Baune, {Bernhard T.} and Bennett, {David A.} and Blackwood, {Douglas H.r.} and Dorret Boomsma and Gerome Breen and Buttensch{\o}n, {Henriette N.} and Byrne, {Enda M.} and B{\o}rglum, {Anders D.} and Enrique Castelao and Sven Cichon and Toni-kim Clarke and Cornelis, {Marilyn C.} and Udo Dannlowski and {De Jager}, {Philip L.} and Ayse Demirkan and Enrico Domenici and {Van Duijn}, {Cornelia M.} and Dunn, {Erin C.} and Eriksson, {Johan G.} and Tonu Esko and Faul, {Jessica D.} and Luigi Ferrucci and Myriam Fornage and Geus, {Eco De} and Michael Gill and Gordon, {Scott D.} and Grabe, {Hans J{\"o}rgen} and Grootheest, {Gerard Van} and Hamilton, {Steven P.} and Hartman, {Catharina A.} and Heath, {Andrew C.} and Karin Hek and Albert Hofman and Georg Homuth and Carsten Horn and Hottenga, {Jouke Jan} and Kardia, {Sharon L.r.} and Stefan Kloiber and Karestan Koenen and Zolt{\'a}n Kutalik and Karl-heinz Ladwig and Jari Lahti and Levinson, {Douglas F.} and Lewis, {Cathryn M.} and Glyn Lewis and Li, {Qingqin S.} and Llewellyn, {David J.} and Susanne Lucae and Lunetta, {Kathryn L.} and Macintyre, {Donald J.} and Pamela Madden and Martin, {Nicholas G.} and Mcintosh, {Andrew M.} and Andres Metspalu and Yuri Milaneschi and Montgomery, {Grant W.} and Ole Mors and Mosley, {Thomas H.} and Murabito, {Joanne M.} and Bertram M{\"u}ller-myhsok and N{\"o}then, {Markus M.} and Nyholt, {Dale R.} and O{\textquoteright}donovan, {Michael C.} and Penninx, {Brenda W.} and Pergadia, {Michele L.} and Roy Perlis and Potash, {James B.} and Martin Preisig and Purcell, {Shaun M.} and Quiroz, {Jorge A.} and Katri R{\"a}ikk{\"o}nen and Rice, {John P.} and Marcella Rietschel and Margarita Rivera and Schulze, {Thomas G.} and Jianxin Shi and Stanley Shyn and Sinnamon, {Grant C.} and Smit, {Johannes H.} and Smoller, {Jordan W.} and Harold Snieder and Toshiko Tanaka and Tansey, {Katherine E.} and Alexander Teumer and Rudolf Uher and Daniel Umbricht and {Der Auwera}, {Sandra Van} and Ware, {Erin B.} and Weir, {David R.} and Weissman, {Myrna M.} and Gonneke Willemsen and Jingyun Yang and Wei Zhao and Henning Tiemeier and Sullivan, {Patrick F.}",

year = "2016",

month = dec,

day = "8",

doi = "10.1016/j.biopsych.2016.11.013",

language = "English",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "ELSEVIER SCIENCE INC",

}

Direk, N, Williams, S, Smith, JA, Ripke, S, Air, T, Amare, AT, Amin, N, Baune, BT, Bennett, DA, Blackwood, DHR, Boomsma, D, Breen, G, Buttenschøn, HN, Byrne, EM, Børglum, AD, Castelao, E, Cichon, S, Clarke, T, Cornelis, MC, Dannlowski, U, De Jager, PL, Demirkan, A, Domenici, E, Van Duijn, CM, Dunn, EC, Eriksson, JG, Esko, T, Faul, JD, Ferrucci, L, Fornage, M, Geus, ED, Gill, M, Gordon, SD, Grabe, HJ, Grootheest, GV, Hamilton, SP, Hartman, CA, Heath, AC, Hek, K, Hofman, A, Homuth, G, Horn, C, Hottenga, JJ, Kardia, SLR, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K, Lahti, J, Levinson, DF, Lewis, CM, Lewis, G, Li, QS, Llewellyn, DJ, Lucae, S, Lunetta, KL, Macintyre, DJ, Madden, P, Martin, NG, Mcintosh, AM, Metspalu, A, Milaneschi, Y, Montgomery, GW, Mors, O, Mosley, TH, Murabito, JM, Müller-myhsok, B, Nöthen, MM, Nyholt, DR, O’donovan, MC, Penninx, BW, Pergadia, ML, Perlis, R, Potash, JB, Preisig, M, Purcell, SM, Quiroz, JA, Räikkönen, K, Rice, JP, Rietschel, M, Rivera, M, Schulze, TG, Shi, J, Shyn, S, Sinnamon, GC, Smit, JH, Smoller, JW, Snieder, H, Tanaka, T, Tansey, KE, Teumer, A, Uher, R, Umbricht, D, Der Auwera, SV, Ware, EB, Weir, DR, Weissman, MM, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, PF 2016, 'An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype', Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2016.11.013

An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype. / Direk, Nese; Williams, Stephanie; Smith, Jennifer A.; Ripke, Stephan; Air, Tracy; Amare, Azmeraw T.; Amin, Najaf; Baune, Bernhard T.; Bennett, David A.; Blackwood, Douglas H.r.; Boomsma, Dorret; Breen, Gerome; Buttenschøn, Henriette N.; Byrne, Enda M.; Børglum, Anders D.; Castelao, Enrique; Cichon, Sven; Clarke, Toni-kim; Cornelis, Marilyn C.; Dannlowski, Udo; De Jager, Philip L.; Demirkan, Ayse; Domenici, Enrico; Van Duijn, Cornelia M.; Dunn, Erin C.; Eriksson, Johan G.; Esko, Tonu; Faul, Jessica D.; Ferrucci, Luigi; Fornage, Myriam; Geus, Eco De; Gill, Michael; Gordon, Scott D.; Grabe, Hans Jörgen; Grootheest, Gerard Van; Hamilton, Steven P.; Hartman, Catharina A.; Heath, Andrew C.; Hek, Karin; Hofman, Albert; Homuth, Georg; Horn, Carsten; Hottenga, Jouke Jan; Kardia, Sharon L.r.; Kloiber, Stefan; Koenen, Karestan; Kutalik, Zoltán; Ladwig, Karl-heinz; Lahti, Jari; Levinson, Douglas F.; Lewis, Cathryn M.; Lewis, Glyn; Li, Qingqin S.; Llewellyn, David J.; Lucae, Susanne; Lunetta, Kathryn L.; Macintyre, Donald J.; Madden, Pamela; Martin, Nicholas G.; Mcintosh, Andrew M.; Metspalu, Andres; Milaneschi, Yuri; Montgomery, Grant W.; Mors, Ole; Mosley, Thomas H.; Murabito, Joanne M.; Müller-myhsok, Bertram; Nöthen, Markus M.; Nyholt, Dale R.; O’donovan, Michael C.; Penninx, Brenda W.; Pergadia, Michele L.; Perlis, Roy; Potash, James B.; Preisig, Martin; Purcell, Shaun M.; Quiroz, Jorge A.; Räikkönen, Katri; Rice, John P.; Rietschel, Marcella; Rivera, Margarita; Schulze, Thomas G.; Shi, Jianxin; Shyn, Stanley; Sinnamon, Grant C.; Smit, Johannes H.; Smoller, Jordan W.; Snieder, Harold; Tanaka, Toshiko; Tansey, Katherine E.; Teumer, Alexander; Uher, Rudolf; Umbricht, Daniel; Der Auwera, Sandra Van; Ware, Erin B.; Weir, David R.; Weissman, Myrna M.; Willemsen, Gonneke; Yang, Jingyun; Zhao, Wei; Tiemeier, Henning; Sullivan, Patrick F.

In: Biological Psychiatry, 08.12.2016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype

AU - Direk, Nese

AU - Williams, Stephanie

AU - Smith, Jennifer A.

AU - Ripke, Stephan

AU - Air, Tracy

AU - Amare, Azmeraw T.

AU - Amin, Najaf

AU - Baune, Bernhard T.

AU - Bennett, David A.

AU - Blackwood, Douglas H.r.

AU - Boomsma, Dorret

AU - Breen, Gerome

AU - Buttenschøn, Henriette N.

AU - Byrne, Enda M.

AU - Børglum, Anders D.

AU - Castelao, Enrique

AU - Cichon, Sven

AU - Clarke, Toni-kim

AU - Cornelis, Marilyn C.

AU - Dannlowski, Udo

AU - De Jager, Philip L.

AU - Demirkan, Ayse

AU - Domenici, Enrico

AU - Van Duijn, Cornelia M.

AU - Dunn, Erin C.

AU - Eriksson, Johan G.

AU - Esko, Tonu

AU - Faul, Jessica D.

AU - Ferrucci, Luigi

AU - Fornage, Myriam

AU - Geus, Eco De

AU - Gill, Michael

AU - Gordon, Scott D.

AU - Grabe, Hans Jörgen

AU - Grootheest, Gerard Van

AU - Hamilton, Steven P.

AU - Hartman, Catharina A.

AU - Heath, Andrew C.

AU - Hek, Karin

AU - Hofman, Albert

AU - Homuth, Georg

AU - Horn, Carsten

AU - Hottenga, Jouke Jan

AU - Kardia, Sharon L.r.

AU - Kloiber, Stefan

AU - Koenen, Karestan

AU - Kutalik, Zoltán

AU - Ladwig, Karl-heinz

AU - Lahti, Jari

AU - Levinson, Douglas F.

AU - Lewis, Cathryn M.

AU - Lewis, Glyn

AU - Li, Qingqin S.

AU - Llewellyn, David J.

AU - Lucae, Susanne

AU - Lunetta, Kathryn L.

AU - Macintyre, Donald J.

AU - Madden, Pamela

AU - Martin, Nicholas G.

AU - Mcintosh, Andrew M.

AU - Metspalu, Andres

AU - Milaneschi, Yuri

AU - Montgomery, Grant W.

AU - Mors, Ole

AU - Mosley, Thomas H.

AU - Murabito, Joanne M.

AU - Müller-myhsok, Bertram

AU - Nöthen, Markus M.

AU - Nyholt, Dale R.

AU - O’donovan, Michael C.

AU - Penninx, Brenda W.

AU - Pergadia, Michele L.

AU - Perlis, Roy

AU - Potash, James B.

AU - Preisig, Martin

AU - Purcell, Shaun M.

AU - Quiroz, Jorge A.

AU - Räikkönen, Katri

AU - Rice, John P.

AU - Rietschel, Marcella

AU - Rivera, Margarita

AU - Schulze, Thomas G.

AU - Shi, Jianxin

AU - Shyn, Stanley

AU - Sinnamon, Grant C.

AU - Smit, Johannes H.

AU - Smoller, Jordan W.

AU - Snieder, Harold

AU - Tanaka, Toshiko

AU - Tansey, Katherine E.

AU - Teumer, Alexander

AU - Uher, Rudolf

AU - Umbricht, Daniel

AU - Der Auwera, Sandra Van

AU - Ware, Erin B.

AU - Weir, David R.

AU - Weissman, Myrna M.

AU - Willemsen, Gonneke

AU - Yang, Jingyun

AU - Zhao, Wei

AU - Tiemeier, Henning

AU - Sullivan, Patrick F.

PY - 2016/12/8

Y1 - 2016/12/8

U2 - 10.1016/j.biopsych.2016.11.013

DO - 10.1016/j.biopsych.2016.11.013

M3 - Article

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

ER -