An Approach to the Efficient Syntheses of Chiral Phosphino-Carboxylic Acid Esters

Renta Jonathan Chew, Kristel Sepp, Bin-Bin Li, Yongxin Li, Peng-Cheng Zhu, Nguan Soon Tan, Pak-Hing Leung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The catalytic hydrophosphination reaction is one of the most sustainable chemical transformations today. Here, the palladium-catalyzed asymmetric P-H addition of diarylphosphines with and analogues is described. Chiral phosphine products are obtained in 100% atom economy and without cumbersome protection-de-protection manipulations. The obtained products can be subsequently transformed to bear various functionalities, including phosphino-carboxylic esters which play critical roles in catalysis and as synthetic aids. Anti-tumour activities of the corresponding gold-phosphine complexes have been explored, contributing to existing chemotherapeutic research in cancer treatment.

Original languageEnglish
Pages (from-to)3297-3302
Number of pages6
JournalAdvanced Synthesis & Catalysis
Volume357
Issue number14-15
DOIs
Publication statusPublished - 12 Oct 2015

Keywords

  • asymmetric catalysis
  • benzotriazoles
  • hydrophosphination
  • palladium
  • phospha-Michael reaction
  • N-ACYLBENZOTRIAZOLES
  • BREAST-CANCER
  • OXIDES
  • DERIVATIVES
  • COMPLEXES
  • LIGANDS
  • DIARYLPHOSPHINES
  • CISPLATIN
  • ACCESS
  • DIPHENYLPHOSPHINE

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