The catalytic hydrophosphination reaction is one of the most sustainable chemical transformations today. Here, the palladium-catalyzed asymmetric P-H addition of diarylphosphines with and analogues is described. Chiral phosphine products are obtained in 100% atom economy and without cumbersome protection-de-protection manipulations. The obtained products can be subsequently transformed to bear various functionalities, including phosphino-carboxylic esters which play critical roles in catalysis and as synthetic aids. Anti-tumour activities of the corresponding gold-phosphine complexes have been explored, contributing to existing chemotherapeutic research in cancer treatment.
- asymmetric catalysis
- phospha-Michael reaction