TY - JOUR
T1 - An automated multiscale ensemble simulation approach for vascular blood flow
AU - Itani, Mohamed A.
AU - Schiller, Ulf D.
AU - Schmieschek, Sebastian
AU - Hetherington, James
AU - Bernabeu, Miguel O.
AU - Chandrashekar, Hoskote
AU - Robertson, Fergus
AU - Coveney, Peter V.
AU - Groen, Derek
PY - 2015/7
Y1 - 2015/7
N2 - Cerebrovascular diseases such as brain aneurysms area primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm formation and rupture. The precise relation is however still an open field of investigation. We present an automated ensemble simulation method for modelling cerebrovascular blood flow under a range of flow regimes. By automatically constructing and performing an ensemble of multiscale simulations, where we unidirectionally couple a 1D solver with a 3D lattice-Boltzmann code, we are able to model the blood flow in a patient artery over a range of flow regimes. We apply the method to a model of a middle cerebral artery, and find that this approach helps us to fine-tune our modelling techniques, and opens up new ways to investigate cerebrovascular flow properties.
AB - Cerebrovascular diseases such as brain aneurysms area primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm formation and rupture. The precise relation is however still an open field of investigation. We present an automated ensemble simulation method for modelling cerebrovascular blood flow under a range of flow regimes. By automatically constructing and performing an ensemble of multiscale simulations, where we unidirectionally couple a 1D solver with a 3D lattice-Boltzmann code, we are able to model the blood flow in a patient artery over a range of flow regimes. We apply the method to a model of a middle cerebral artery, and find that this approach helps us to fine-tune our modelling techniques, and opens up new ways to investigate cerebrovascular flow properties.
KW - Multiscale modelling
KW - Blood flow
KW - Ensemble simulation
KW - Parallel programming
KW - High-performance computing
U2 - 10.1016/j.jocs.2015.04.008
DO - 10.1016/j.jocs.2015.04.008
M3 - Article
VL - 9
SP - 150
EP - 155
JO - Journal of Computational Science
JF - Journal of Computational Science
SN - 1877-7503
ER -