An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic beta-cell

Abdelilah Arredouani, A. Mark Evans, Jianjie Ma, John Parrington, Michael X. Zhu, Antony Galione

Research output: Contribution to journalEditorialpeer-review

Abstract / Description of output

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic beta-cells. 1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic beta-cell.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalIslets
Volume2
Issue number5
DOIs
Publication statusPublished - 2010

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