An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic beta-cell

Abdelilah Arredouani; A. Mark Evans; Jianjie Ma; John Parrington; Michael X. Zhu; Antony Galione

doi:10.4161/isl.2.5.12747

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic beta-cell

Abdelilah Arredouani, A. Mark Evans, Jianjie Ma, John Parrington, Michael X. Zhu, Antony Galione

Deanery of Biomedical Sciences

Research output: Contribution to journal › Editorial › peer-review

Abstract

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic beta-cells. 1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic beta-cell.

Original language	English
Pages (from-to)	323-330
Number of pages	8
Journal	Islets
Volume	2
Issue number	5
DOIs	https://doi.org/10.4161/isl.2.5.12747
Publication status	Published - 2010

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Arredouani et al 2010Submitted manuscript, 668 KB

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title = "An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic beta-cell",

abstract = "Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic beta-cells. 1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic beta-cell.",

author = "Abdelilah Arredouani and Evans, {A. Mark} and Jianjie Ma and John Parrington and Zhu, {Michael X.} and Antony Galione",

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AU - Arredouani, Abdelilah

AU - Evans, A. Mark

AU - Ma, Jianjie

AU - Parrington, John

AU - Zhu, Michael X.

AU - Galione, Antony

PY - 2010

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N2 - Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic beta-cells. 1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic beta-cell.

AB - Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic beta-cells. 1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic beta-cell.

U2 - 10.4161/isl.2.5.12747

DO - 10.4161/isl.2.5.12747

M3 - Editorial

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SP - 323

EP - 330

JO - Islets

JF - Islets

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ER -

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic beta-cell

Abstract

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