An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

Abdelilah Arredouani; A Mark Evans; Jianjie Ma; John Parrington; Michael X Zhu; Antony Galione

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

Abdelilah Arredouani, A Mark Evans, Jianjie Ma, John Parrington, Michael X Zhu, Antony Galione

Deanery of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

Original language	English
Pages (from-to)	323-30
Number of pages	8
Journal	Islets
Volume	2
Issue number	5
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

Animals
Calcium
Calcium Channels
Calcium Signaling
Humans
Insulin-Secreting Cells
NADP

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https://www.landesbioscience.com/journals/islets/article/12747/?nocache=1698949917

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title = "An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell",

abstract = "Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.",

keywords = "Animals, Calcium, Calcium Channels, Calcium Signaling, Humans, Insulin-Secreting Cells, NADP",

author = "Abdelilah Arredouani and Evans, {A Mark} and Jianjie Ma and John Parrington and Zhu, {Michael X} and Antony Galione",

year = "2010",

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T1 - An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

AU - Arredouani, Abdelilah

AU - Evans, A Mark

AU - Ma, Jianjie

AU - Parrington, John

AU - Zhu, Michael X

AU - Galione, Antony

PY - 2010

Y1 - 2010

N2 - Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

AB - Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

KW - Animals

KW - Calcium

KW - Calcium Channels

KW - Calcium Signaling

KW - Humans

KW - Insulin-Secreting Cells

KW - NADP

M3 - Article

C2 - 21099331

SN - 1938-2014

VL - 2

SP - 323

EP - 330

JO - Islets

JF - Islets

IS - 5

ER -

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

Abstract

Keywords / Materials (for Non-textual outputs)

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