An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Olivia Hamilton, Qian Zhang, Allan F. Mcrae, Rosie Walker, Stewart Morris, Paul Redmond, Archibald Campbell, Alison Murray, David Porteous, Kathryn Evans, Andrew McIntosh, Ian Deary, Riccardo Marioni

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936. This study also tests whether these associations are independent of phenotypic BMI.
Original languageEnglish
JournalInternational Journal of Obesity
DOIs
Publication statusPublished - 6 Mar 2019

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