An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Olivia Hamilton; Qian Zhang; Allan F. Mcrae; Rosie Walker; Stewart Morris; Paul Redmond; Archibald Campbell; Alison Murray; David Porteous; Kathryn Evans; Andrew McIntosh; Ian Deary; Riccardo Marioni

doi:10.1038/s41366-018-0262-3

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Olivia Hamilton, Qian Zhang, Allan F. Mcrae, Rosie Walker, Stewart Morris, Paul Redmond, Archibald Campbell, Alison Murray, David Porteous, Kathryn Evans, Andrew McIntosh, Ian Deary, Riccardo Marioni

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936. This study also tests whether these associations are independent of phenotypic BMI.

Original language	English
Journal	International Journal of Obesity
DOIs	https://doi.org/10.1038/s41366-018-0262-3
Publication status	Published - 6 Mar 2019

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10.1038/s41366-018-0262-3Licence: Creative Commons: Attribution (CC-BY)

Hamilton (2019) Int J Obesity bmi epigenetic score correlationsFinal published version, 518 KBLicence: Creative Commons: Attribution (CC-BY)

The Disconnected Mind Phase 3
Wardlaw, J. (Principal Investigator)
UK-based charities
1/04/16 → 30/09/20
Project: Research
Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J. (Principal Investigator), Bastin, M. (Co-investigator) & Deary, I. (Co-investigator)
MRC
1/05/15 → 30/04/19
Project: Research
Stratifying Resilience and Depression Longitudinally
McIntosh, A. (Principal Investigator), Deary, I. (Co-investigator), Evans, K. (Co-investigator), Haley, C. (Co-investigator) & Porteous, D. (Co-investigator)
UK-based charities
1/01/15 → 30/06/21
Project: Research

Combining genomic and imaging data in studies of depression
McIntosh, A. (Keynote speaker)
15 Mar 2019
Activity: Academic talk or presentation types › Invited talk

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Cite this

Hamilton, O., Zhang, Q., Mcrae, A. F., Walker, R., Morris, S., Redmond, P., Campbell, A., Murray, A., Porteous, D., Evans, K., McIntosh, A., Deary, I., & Marioni, R. (2019). An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort. International Journal of Obesity. https://doi.org/10.1038/s41366-018-0262-3

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title = "An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort",

abstract = "The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936. This study also tests whether these associations are independent of phenotypic BMI.",

author = "Olivia Hamilton and Qian Zhang and Mcrae, {Allan F.} and Rosie Walker and Stewart Morris and Paul Redmond and Archibald Campbell and Alison Murray and David Porteous and Kathryn Evans and Andrew McIntosh and Ian Deary and Riccardo Marioni",

year = "2019",

month = mar,

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doi = "10.1038/s41366-018-0262-3",

language = "English",

journal = "International Journal of Obesity",

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Hamilton, O, Zhang, Q, Mcrae, AF, Walker, R, Morris, S, Redmond, P, Campbell, A, Murray, A, Porteous, D, Evans, K , McIntosh, A , Deary, I & Marioni, R 2019, 'An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort', International Journal of Obesity. https://doi.org/10.1038/s41366-018-0262-3

TY - JOUR

T1 - An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

AU - Hamilton, Olivia

AU - Zhang, Qian

AU - Mcrae, Allan F.

AU - Walker, Rosie

AU - Morris, Stewart

AU - Redmond, Paul

AU - Campbell, Archibald

AU - Murray, Alison

AU - Porteous, David

AU - Evans, Kathryn

AU - McIntosh, Andrew

AU - Deary, Ian

AU - Marioni, Riccardo

PY - 2019/3/6

Y1 - 2019/3/6

N2 - The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936. This study also tests whether these associations are independent of phenotypic BMI.

AB - The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936. This study also tests whether these associations are independent of phenotypic BMI.

U2 - 10.1038/s41366-018-0262-3

DO - 10.1038/s41366-018-0262-3

M3 - Article

SN - 0307-0565

JO - International Journal of Obesity

JF - International Journal of Obesity

ER -

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Abstract

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Projects

The Disconnected Mind Phase 3

Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

Stratifying Resilience and Depression Longitudinally

Activities

Combining genomic and imaging data in studies of depression

Cite this