An estimation of the number of susceptibility loci for isolated cleft palate

D FitzPatrick, M Farrall

Research output: Contribution to journalArticlepeer-review

Abstract

The existence of a major gene (or genes) that contributes significantly to the familial clustering of cleft lip with or without cleft palate (CL(P)) has been suggested by genetic epidemiology studies and supported by patient-control genotype association studies with a candidate gene. Here we present an analysis of the familial recurrence risk data for isolated cleft palate (CP) and show that an oligogenic model with six genes of equal effect fits the data best. The discrimination between alternative models is, however, poor and a major locus that explains half of the familial recurrence is plausible. The prospects for identification of susceptibility loci for CP are discussed.
Original languageEnglish
Pages (from-to)230-5
Number of pages6
JournalJournal of craniofacial genetics and developmental biology
Volume13
Issue number4
Publication statusPublished - 1993

Keywords

  • Cleft Lip
  • Cleft Palate
  • Cluster Analysis
  • Denmark
  • France
  • Humans
  • Models, Genetic
  • Risk Factors
  • Scotland
  • United States

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