An evaluation of deformation-based morphometry applied to the developing human brain and detection of volumetric changes associated with preterm birth

JP Boardman*, K Bhatia, S Counsell, J Allsop, O Kapellou, MA Rutherford, AD Edwards, JV Hajnal, D Rueckert

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Deformation-based morphometry enables the automatic quantification of neuroanatomical differences by measuring regional shape and volume differences between a reference space and the population under investigation. In this paper we use deformation-based morphometric methods to study volumetric differences between preterm infants at term equivalent age and term born controls using high-resolution MR imaging, and we investigate the influence of the choice of reference image on results obtained. We constructed mean atlases of preterm infants at term equivalent age and term born infants using three different reference spaces, and used them to compare the brains of the two groups. A non-rigid registration algorithm was used to map all 3 atlases into a common coordinate system and volumetric differences were extracted. Our results demonstrate significant volume differences between preterm infants at term equivalent age and the control group in the ventricular system, the interhemispheric fissure anteriorly, and the globus pallidus and thalamus. Morphometric changes are consistent between all three maps of volume change and indicate that the results obtained using deformation-based morphometry are largely independent of the choice of the reference space.

Original languageEnglish
Title of host publicationMEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2003, PT 1
EditorsRE Ellis, TM Peters
PublisherSpringer-Verlag Berlin Heidelberg
Pages697-704
Number of pages8
ISBN (Print)3-540-20462-8
Publication statusPublished - 2003
Event6th International Conference on Medical Imaging Computing and Computer-Assisted Intervention - MONTREAL, Canada
Duration: 15 Nov 200318 Nov 2003

Publication series

NameLECTURE NOTES IN COMPUTER SCIENCE
PublisherSPRINGER-VERLAG BERLIN
Volume2878
ISSN (Print)0302-9743

Conference

Conference6th International Conference on Medical Imaging Computing and Computer-Assisted Intervention
CountryCanada
CityMONTREAL
Period15/11/0318/11/03

Keywords

  • INFANTS
  • TERM
  • CHILDREN
  • WEIGHT

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