An experimental study of the putative mechanism of a synthetic autonomous rotary DNA nanomotor

Katherine Elizabeth Dunn, Mark Christian Leake, Adam Wollman, Martin Albrecht Trefzer, Steven David Johnson, Andy Tyrrell

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

DNA has been used to construct a wide variety of nanoscale molecular devices. Inspiration for such synthetic molecular machines is frequently drawn from protein motors, which are naturally occurring and ubiquitous. However, despite the fact that rotary motors such as ATP synthase and the bacterial flagellar motor play extremely important roles in nature, very few rotary devices have been constructed using DNA. This paper describes an experimental study of the putative mechanism of a rotary DNA nanomotor, which is based on strand displacement, the phenomenon that powers many synthetic linear DNA motors. Unlike other examples of rotary DNA machines, the device described here is designed to be capable of autonomous operation after it is triggered. The experimental results are consistent with operation of the motor as expected, and future work on an enhanced motor design may allow rotation to be observed at the single-molecule level. The rotary motor concept presented here has potential applications in molecular processing, DNA computing, biosensing and photonics.
Original languageEnglish
Article number160767
JournalRoyal Society Open Science
Volume4
Issue number3
Early online date22 Mar 2017
DOIs
Publication statusE-pub ahead of print - 22 Mar 2017

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