An Expression QTL of Closely Linked Candidate Genes Affects pH of Meat in Chickens

Javad Nadaf, Cecile Berri, Ian Dunn, Estelle Godet, Elisabeth Le Bihan-Duval, Dirk-Jan de Koning

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Genetical genomics has been suggested as a powerful approach to study the genotype-phenotype gap. However, the relatively low power of these experiments (usually related to the high cost) has hindered fulfilment of its promise, especially for loci (QTL) of moderate effects. One strategy to overcome the issue is to use a targeted approach. It has two clear advantages: (i) it reduces the problem to a simple comparison between different genotypic groups at the QTL and (ii) it is a good starting point to investigate downstream effects of the QTL. In the present study, from 698 F2 birds used for QTL mapping, gene expression profiles of 24 birds with divergent homozygous QTL genotypes were investigated. The targeted QTL was on chromosome 1 and affected initial pH of breast muscle. The biological mechanisms controlling this trait can be similar to those affecting malignant hyperthermia or muscle fatigue in human. The gene expression study identified ten strong local signals which were markedly more significant compared to any genes on the rest of the genome. The differentially expressed genes all mapped to a region
Original languageEnglish
Pages (from-to)867-874
Issue number3
Early online date3 Jan 2014
Publication statusPublished - 3 Jan 2014


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