An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

Abigail K Langton, Sarah E Herrick, Denis J Headon

Research output: Contribution to journalArticlepeer-review

Abstract

Hair follicles have been observed to provide a major cellular contribution to epidermal healing, with emigration of stem-derived cells from the follicles aiding in wound reepithelialization. However, the functional requirements for this hair follicle input are unknown. Here we have characterized the keratinocyte stem cell status of mutant mice that lack all hair follicle development on their tail, and analyzed the consequent alterations in epidermal wound healing rate and mechanisms. In analyzing stem cell behavior in embryonic skin we found that clonogenic keratinocytes are relatively frequent in the ectoderm prior to hair follicle formation. However, their frequency in the interfollicular epidermis drops sharply by birth, at which time the majority of stem cells are present within the hair follicles. We find that in the absence of hair follicles cutaneous wounds heal with an acute delay in reepithelialization. This delay is followed by expansion of the region of activated epidermis, beyond that seen in normal haired skin, followed by appropriate wound closure.
Original languageEnglish
Pages (from-to)1311-1318
Number of pages8
JournalJournal of Investigative Dermatology
Volume128
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • 3T3 Cells
  • Animals
  • Edar-Associated Death Domain Protein
  • Epidermis
  • Female
  • Hair Follicle
  • Keratinocytes
  • Male
  • Mice
  • Mice, Mutant Strains
  • Pregnancy
  • Skin
  • Stem Cells
  • Wound Healing

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