An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients

Pamela Traynor, Liane M. McGlynn, Rono Mukhergee, Samuel J. S. Grimsley, John M. S. Bartlett, Joanne Edwards

Research output: Contribution to journalArticlepeer-review

Abstract

Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K-Ras was not associated with any known clinical parameters. In contrast an increase in N-Ras membrane expression in the transition from hormone sensitive to hormone refractory prostate cancer was associated with shorter time to relapse (p = 0.01) and shorter disease specific survival (p = 0.008). In addition, patients with an increase in N-Ras membrane expression had lower levels of PSA at relapse (p = 0.02) and expression correlated with phosphorylated MAP kinase (p = 0.010) and proliferation index (Ki67, p = 0.02). These results suggest that in a subgroup patients N-Ras expression is associated with development of hormone refractory prostate cancer via activation of the MAP kinase cascade.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalDisease Markers
Volume24
Issue number3
Publication statusPublished - 2008

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