An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins

H. M. Burgess, N. K. Gray

Research output: Contribution to journalArticlepeer-review

Abstract

Cytoplasmic poly(A)-binding proteins (PABPs) regulate mRNA stability and translation. Although predominantly localized in the cytoplasm, PABP proteins also cycle through the nucleus. Recent work has established that their steady-state localization can be altered by cellular stresses such as ultraviolet (UV) radiation, and infection by several viruses, resulting in nuclear accumulation of PABPs. Here, we present further evidence that their interaction with and release from mRNA and translation complexes are important in determining their sub-cellular distribution and propose an integrated model for regulated nucleo-cytoplasmic transport of PABPs.
Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalCommunicative and Integrative Biology
Volume5
Issue number3
DOIs
Publication statusPublished - May 2012

Keywords

  • PABP
  • PABPC1
  • PABPC4
  • RNA-binding protein
  • cellular stress response
  • nucleo-cytoplasmic transport

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