Projects per year
Abstract / Description of output
Cytoplasmic poly(A)-binding proteins (PABPs) regulate mRNA stability and translation. Although predominantly localized in the cytoplasm, PABP proteins also cycle through the nucleus. Recent work has established that their steady-state localization can be altered by cellular stresses such as ultraviolet (UV) radiation, and infection by several viruses, resulting in nuclear accumulation of PABPs. Here, we present further evidence that their interaction with and release from mRNA and translation complexes are important in determining their sub-cellular distribution and propose an integrated model for regulated nucleo-cytoplasmic transport of PABPs.
Keywords / Materials (for Non-textual outputs)
- RNA-binding protein
- cellular stress response
- nucleo-cytoplasmic transport
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- 1 Finished
Poly (A)-binding proteins highlighted the importance of regulated mRNA translation and stability in determing a functional materno-fetal interface
Gray, N., Girardi, G. & Norman, J.
1/04/12 → 30/09/17