An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case-control studies

Hsin-yi Yang, Sui-lung Su, Yi-jen Peng, Chih-chien Wang, Herng-sheng Lee, Donald M Salter, Chian-her Lee

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Knee osteoarthritis (OA) is a complex disease involving both biomechanical and metabolic factors that alter the tissue homeostasis of articular cartilage and subchondral bone. The catabolic activities of extracellular matrix degradation products, especially fibronectin (FN), have been implicated in mediating cartilage degradation. Chondrocytes express several members of the integrin family which can serve as receptors for FN including integrins α5β1, αvβ3, and αvβ5. The purpose of this study was to determine whether polymorphisms in the FN (FN-1) and integrin genes are markers of susceptibility to, or severity of, knee OA in a Han Chinese population.
Original languageEnglish
Article number173
JournalBMC Musculoskeletal Disorders
Volume15
Issue number1
DOIs
Publication statusPublished - 23 May 2014

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