An undernutrition screening score for dogs with protein‐losing enteropathy: A prospective multicenter study

Florence E. Wootton, Christopher S. F. K Hoey , Glynn Woods, Silke Salavati, Jenny Reeve, Jennifer Larsen, Aarti Kathrani

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background
The impact of undernutrition in dogs with protein-losing enteropathy (PLE) caused by inflammatory enteritis, intestinal lymphangiectasia, or both and which variables are most predictive of outcome are unknown.

Objectives
Develop an undernutrition screening score (USS) for use at the time of diagnosis of PLE in dogs, which is predictive of outcome.

Animals
Fifty-seven dogs with PLE prospectively recruited from 3 referral hospitals in the United Kingdom.

Methods
An USS based on the presence and severity of 5 variables: appetite, weight loss, and body, muscle, and coat condition and scored out of 15, with higher scores reflecting worse undernutrition, was calculated at the time of diagnosis. Follow-up information was obtained for at least 6 months.

Results
Dogs that failed to achieve clinical remission within 6 months had higher USS at diagnosis compared with dogs that achieved remission (median, 7.5; range, 2-14 and median, 5; range, 0-14, respectively). The USS at diagnosis gave an area under the receiver operating characteristic curve (AUC) of 0.656 for predicting nonclinical remission within 6 months, whereas a score consisting of just epaxial muscle loss and coat condition resulted in a larger AUC of 0.728.

Conclusions and Clinical Importance
Of the 5 variables assessed in the USS, a combination of epaxial muscle loss and coat condition was most predictive of not achieving clinical remission within 6 months in dogs with PLE. Additional studies will help determine the effect of changes in USS and the 5 associated variables after diagnosis on outcome variables in these dogs.
Original languageEnglish
Pages (from-to)1821-1829
Number of pages9
JournalJournal of Veterinary Internal Medicine
Volume37
Issue number5
Early online date21 Jul 2023
DOIs
Publication statusPublished - 1 Sept 2023

Keywords / Materials (for Non-textual outputs)

  • canine
  • diarrhea
  • gastrointestinal
  • malnutrition

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