An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors

Mitsunori Watanabe, Yoshiki Adachi, Mandy Jackson, Yukiko Yamamoto-Watanabe, Yasuhito Wakasaya, Ikumi Shirahama, Ayumi Takamura, Etsuro Matsubara, Takeshi Kawarabayashi, Mikio Shoji

Research output: Contribution to journalArticlepeer-review

Abstract

Here we report a female patient with elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). At age 71, she developed gait disturbance, followed by memory disturbance 1 year later. She had been treated for hypertension and diabetes mellitus for 19 years. There apparently was low penetrance of disease. Magnetic resonance imaging (MRI) findings showed typical features of CADASIL, and the R607C mutation was detected in exon 11 in NOTCH3. This case strongly indicates that CADASIL should be considered when typical findings are observed on MRI even in cases of elderly onset with multiple cerebrovascular risk factors.
Original languageEnglish
Pages (from-to)143-5
Number of pages3
JournalJournal of Stroke and Cerebrovascular Diseases
Volume21
Issue number2
DOIs
Publication statusPublished - 2012

Fingerprint

Dive into the research topics of 'An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors'. Together they form a unique fingerprint.

Cite this