An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors

Mitsunori Watanabe; Yoshiki Adachi; Mandy Jackson; Yukiko Yamamoto-Watanabe; Yasuhito Wakasaya; Ikumi Shirahama; Ayumi Takamura; Etsuro Matsubara; Takeshi Kawarabayashi; Mikio Shoji

doi:10.1016/j.jstrokecerebrovasdis.2010.05.008

An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors

Mitsunori Watanabe, Yoshiki Adachi, Mandy Jackson, Yukiko Yamamoto-Watanabe, Yasuhito Wakasaya, Ikumi Shirahama, Ayumi Takamura, Etsuro Matsubara, Takeshi Kawarabayashi, Mikio Shoji

Deanery of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Here we report a female patient with elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). At age 71, she developed gait disturbance, followed by memory disturbance 1 year later. She had been treated for hypertension and diabetes mellitus for 19 years. There apparently was low penetrance of disease. Magnetic resonance imaging (MRI) findings showed typical features of CADASIL, and the R607C mutation was detected in exon 11 in NOTCH3. This case strongly indicates that CADASIL should be considered when typical findings are observed on MRI even in cases of elderly onset with multiple cerebrovascular risk factors.

Original language	English
Pages (from-to)	143-5
Number of pages	3
Journal	Journal of Stroke & Cerebrovascular Diseases
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.jstrokecerebrovasdis.2010.05.008
Publication status	Published - 2012

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Watanabe, M., Adachi, Y., Jackson, M., Yamamoto-Watanabe, Y., Wakasaya, Y., Shirahama, I., Takamura, A., Matsubara, E., Kawarabayashi, T., & Shoji, M. (2012). An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors. Journal of Stroke & Cerebrovascular Diseases, 21(2), 143-5. https://doi.org/10.1016/j.jstrokecerebrovasdis.2010.05.008

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title = "An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors",

abstract = "Here we report a female patient with elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). At age 71, she developed gait disturbance, followed by memory disturbance 1 year later. She had been treated for hypertension and diabetes mellitus for 19 years. There apparently was low penetrance of disease. Magnetic resonance imaging (MRI) findings showed typical features of CADASIL, and the R607C mutation was detected in exon 11 in NOTCH3. This case strongly indicates that CADASIL should be considered when typical findings are observed on MRI even in cases of elderly onset with multiple cerebrovascular risk factors.",

author = "Mitsunori Watanabe and Yoshiki Adachi and Mandy Jackson and Yukiko Yamamoto-Watanabe and Yasuhito Wakasaya and Ikumi Shirahama and Ayumi Takamura and Etsuro Matsubara and Takeshi Kawarabayashi and Mikio Shoji",

year = "2012",

doi = "10.1016/j.jstrokecerebrovasdis.2010.05.008",

language = "English",

volume = "21",

pages = "143--5",

journal = "Journal of Stroke & Cerebrovascular Diseases",

publisher = "Elsevier",

number = "2",

}

Watanabe, M, Adachi, Y, Jackson, M, Yamamoto-Watanabe, Y, Wakasaya, Y, Shirahama, I, Takamura, A, Matsubara, E, Kawarabayashi, T & Shoji, M 2012, 'An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors', Journal of Stroke & Cerebrovascular Diseases, vol. 21, no. 2, pp. 143-5. https://doi.org/10.1016/j.jstrokecerebrovasdis.2010.05.008

An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors. / Watanabe, Mitsunori; Adachi, Yoshiki; Jackson, Mandy et al.
In: Journal of Stroke & Cerebrovascular Diseases, Vol. 21, No. 2, 2012, p. 143-5.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors

AU - Watanabe, Mitsunori

AU - Adachi, Yoshiki

AU - Jackson, Mandy

AU - Yamamoto-Watanabe, Yukiko

AU - Wakasaya, Yasuhito

AU - Shirahama, Ikumi

AU - Takamura, Ayumi

AU - Matsubara, Etsuro

AU - Kawarabayashi, Takeshi

AU - Shoji, Mikio

PY - 2012

Y1 - 2012

N2 - Here we report a female patient with elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). At age 71, she developed gait disturbance, followed by memory disturbance 1 year later. She had been treated for hypertension and diabetes mellitus for 19 years. There apparently was low penetrance of disease. Magnetic resonance imaging (MRI) findings showed typical features of CADASIL, and the R607C mutation was detected in exon 11 in NOTCH3. This case strongly indicates that CADASIL should be considered when typical findings are observed on MRI even in cases of elderly onset with multiple cerebrovascular risk factors.

AB - Here we report a female patient with elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). At age 71, she developed gait disturbance, followed by memory disturbance 1 year later. She had been treated for hypertension and diabetes mellitus for 19 years. There apparently was low penetrance of disease. Magnetic resonance imaging (MRI) findings showed typical features of CADASIL, and the R607C mutation was detected in exon 11 in NOTCH3. This case strongly indicates that CADASIL should be considered when typical findings are observed on MRI even in cases of elderly onset with multiple cerebrovascular risk factors.

U2 - 10.1016/j.jstrokecerebrovasdis.2010.05.008

DO - 10.1016/j.jstrokecerebrovasdis.2010.05.008

M3 - Article

C2 - 20851625

VL - 21

SP - 143

EP - 145

JO - Journal of Stroke & Cerebrovascular Diseases

JF - Journal of Stroke & Cerebrovascular Diseases

IS - 2

ER -

Watanabe M, Adachi Y, Jackson M, Yamamoto-Watanabe Y, Wakasaya Y, Shirahama I et al. An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors. Journal of Stroke & Cerebrovascular Diseases. 2012;21(2):143-5. doi: 10.1016/j.jstrokecerebrovasdis.2010.05.008

An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factors

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