An unusual case of Wilson's disease

J W Madden, J W Ironside, D R Triger, J P Bradshaw

Research output: Contribution to journalArticlepeer-review

Abstract

A man of 61 with a 26-year history of progressive cerebellar ataxia was admitted to hospital. He was found to have chronic liver disease and died 22 days after admission. A diagnosis of hepatolenticular degeneration (Wilson's disease) was supported by clinical investigations and confirmed at autopsy, when tissue copper studies were performed. Several unusual features were present, including a unilateral Kayser-Fleischer ring, a hepatocellular carcinoma, peripheral neuropathy, pontine demyelination and calcification of neurones in the medulla. The significance of these findings is discussed with a review of the relevant literature.

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalQuarterly journal of medicine
Volume55
Issue number216
Publication statusPublished - Apr 1985

Keywords

  • Brain
  • Carcinoma, Hepatocellular
  • Copper
  • Hepatolenticular Degeneration
  • Humans
  • Liver
  • Liver Neoplasms
  • Male
  • Middle Aged

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