Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain

Clare J Proudfoot, Emer M Garry, David F Cottrell, Roberta Rosie, Heather Anderson, Darren C Robertson, Susan M Fleetwood-Walker, Rory Mitchell

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic established pain, especially that following nerve injury, is difficult to treat and represents a largely unmet therapeutic need. New insights are urgently required, and we reasoned that endogenous processes such as cooling-induced analgesia may point the way to novel strategies for intervention. Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states.
Original languageEnglish
Pages (from-to)1591-605
Number of pages15
JournalCurrent biology : CB
Volume16
Issue number16
DOIs
Publication statusPublished - 22 Aug 2006

Keywords

  • Acrolein
  • Amino Acids
  • Analgesia
  • Analysis of Variance
  • Animals
  • Blotting, Western
  • Cold Temperature
  • Dose-Response Relationship, Drug
  • Electrophysiology
  • Immunohistochemistry
  • Male
  • Menthol
  • Neuralgia
  • Oligonucleotides, Antisense
  • Pyrimidinones
  • Rats
  • Rats, Wistar
  • Receptors, Glutamate
  • Reflex
  • TRPM Cation Channels
  • Xanthenes

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