Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain

Clare J Proudfoot; Emer M Garry; David F Cottrell; Roberta Rosie; Heather Anderson; Darren C Robertson; Susan M Fleetwood-Walker; Rory Mitchell

doi:10.1016/j.cub.2006.07.061

Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain

Clare J Proudfoot, Emer M Garry, David F Cottrell, Roberta Rosie, Heather Anderson, Darren C Robertson, Susan M Fleetwood-Walker, Rory Mitchell

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Chronic established pain, especially that following nerve injury, is difficult to treat and represents a largely unmet therapeutic need. New insights are urgently required, and we reasoned that endogenous processes such as cooling-induced analgesia may point the way to novel strategies for intervention. Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states.

Original language	English
Pages (from-to)	1591-605
Number of pages	15
Journal	Current biology : CB
Volume	16
Issue number	16
DOIs	https://doi.org/10.1016/j.cub.2006.07.061
Publication status	Published - 22 Aug 2006

Keywords / Materials (for Non-textual outputs)

Acrolein
Amino Acids
Analgesia
Analysis of Variance
Animals
Blotting, Western
Cold Temperature
Dose-Response Relationship, Drug
Electrophysiology
Immunohistochemistry
Male
Menthol
Neuralgia
Oligonucleotides, Antisense
Pyrimidinones
Rats
Rats, Wistar
Receptors, Glutamate
Reflex
TRPM Cation Channels
Xanthenes

Access to Document

10.1016/j.cub.2006.07.061

Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic painAccepted author manuscript, 6.56 MB

http://www.cell.com/current-biology/retrieve/pii/S0960982206019701

Cite this

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title = "Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain",

abstract = "Chronic established pain, especially that following nerve injury, is difficult to treat and represents a largely unmet therapeutic need. New insights are urgently required, and we reasoned that endogenous processes such as cooling-induced analgesia may point the way to novel strategies for intervention. Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states.",

keywords = "Acrolein, Amino Acids, Analgesia, Analysis of Variance, Animals, Blotting, Western, Cold Temperature, Dose-Response Relationship, Drug, Electrophysiology, Immunohistochemistry, Male, Menthol, Neuralgia, Oligonucleotides, Antisense, Pyrimidinones, Rats, Rats, Wistar, Receptors, Glutamate, Reflex, TRPM Cation Channels, Xanthenes",

author = "Proudfoot, {Clare J} and Garry, {Emer M} and Cottrell, {David F} and Roberta Rosie and Heather Anderson and Robertson, {Darren C} and Fleetwood-Walker, {Susan M} and Rory Mitchell",

year = "2006",

month = aug,

day = "22",

doi = "10.1016/j.cub.2006.07.061",

language = "English",

volume = "16",

pages = "1591--605",

journal = "Current biology : CB",

issn = "0960-9822",

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number = "16",

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T1 - Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain

AU - Proudfoot, Clare J

AU - Garry, Emer M

AU - Cottrell, David F

AU - Rosie, Roberta

AU - Anderson, Heather

AU - Robertson, Darren C

AU - Fleetwood-Walker, Susan M

AU - Mitchell, Rory

PY - 2006/8/22

Y1 - 2006/8/22

N2 - Chronic established pain, especially that following nerve injury, is difficult to treat and represents a largely unmet therapeutic need. New insights are urgently required, and we reasoned that endogenous processes such as cooling-induced analgesia may point the way to novel strategies for intervention. Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states.

AB - Chronic established pain, especially that following nerve injury, is difficult to treat and represents a largely unmet therapeutic need. New insights are urgently required, and we reasoned that endogenous processes such as cooling-induced analgesia may point the way to novel strategies for intervention. Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states.

KW - Acrolein

KW - Amino Acids

KW - Analgesia

KW - Analysis of Variance

KW - Animals

KW - Blotting, Western

KW - Cold Temperature

KW - Dose-Response Relationship, Drug

KW - Electrophysiology

KW - Immunohistochemistry

KW - Male

KW - Menthol

KW - Neuralgia

KW - Oligonucleotides, Antisense

KW - Pyrimidinones

KW - Rats

KW - Rats, Wistar

KW - Receptors, Glutamate

KW - Reflex

KW - TRPM Cation Channels

KW - Xanthenes

U2 - 10.1016/j.cub.2006.07.061

DO - 10.1016/j.cub.2006.07.061

M3 - Article

C2 - 16920620

SN - 0960-9822

VL - 16

SP - 1591

EP - 1605

JO - Current biology : CB

JF - Current biology : CB

IS - 16

ER -

Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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