ANALYSIS OF CANDIDATE HUMAN BLOOD STEM-CELLS IN HUMANIZED IMMUNE-DEFICIENCY SCID MICE

B PEAULT, I WEISSMAN, C BAUM

Research output: Contribution to journalArticlepeer-review

Abstract

Immune deficient SCID mice support the hematopoietic development of surgically implanted human fetal thymus and bone. The usability of the resulting SCID-hu hematolymphoid chimaera as an assay system for human candidate blood stem cells was suggested by the observation that allogeneic CD34+ cells sorted from fetal liver and bone marrow can engraft and differentiate in the transplanted human thymus and bone marrow. The SCID-hu mouse has been further used, in combination with a mouse bone marrow stromal cell line that supports human myeloid and B lymphoid differentiation in vitro, to identify a minor subset of fetal CD34-expressing cells that exhibit multilineage hematopoietic potentialities.

Original languageEnglish
Pages (from-to)S98-S101
Number of pages4
JournalLeukemia
Volume7
Publication statusPublished - Aug 1993

Cite this