Analysis of electroencephalograms in Alzheimer's disease patients with multiscale entropy

J. Escudero*, D. Abasolo, R. Hornero, P. Espino, M. Lopez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to analyse the electroencephalogram ( EEG) background activity of Alzheimer's disease ( AD) patients using multiscale entropy (MSE). MSE is a recently developed method that quantifies the regularity of a signal on different time scales. These time scales are inspected by means of several coarse-grained sequences formed from the analysed signals. We recorded the EEGs from 19 scalp electrodes in 11 AD patients and 11 age-matched controls and estimated the MSE profile for each epoch of the EEG recordings. The shape of the MSE profiles reveals the EEG complexity, and it suggests that the EEG contains information in deeper scales than the smallest one. Moreover, the results showed that the EEG background activity is less complex in AD patients than control subjects. We found significant differences between both subject groups at electrodes F3, F7, Fp1, Fp2, T5, T6, P3, P4, O1 and O2 (p-value <0.01, Student's t-test). These findings indicate that the EEG complexity analysis performed on deeper time scales by MSE may be a useful tool in order to increase our knowledge of AD.

Original languageEnglish
Pages (from-to)1091-1106
Number of pages16
JournalPhysiological Measurement
Volume27
Issue number11
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Alzheimer's disease
  • electroencephalogram
  • multiscale entropy
  • complexity
  • time scales
  • EEG BACKGROUND ACTIVITY
  • APPROXIMATE ENTROPY
  • TIME-SERIES
  • LYAPUNOV EXPONENTS
  • STRANGE ATTRACTORS
  • SAMPLE ENTROPY
  • COMPLEXITY
  • REGULARITY
  • DEPTH
  • INFORMATION

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