Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies

Carlos Gomez; Roberto Hornero; Daniel Abasolo; Alberto Fernandez; Javier Escudero

Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies

Carlos Gomez^*, Roberto Hornero, Daniel Abasolo, Alberto Fernandez, Javier Escudero

^*Corresponding author for this work

School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Alzheimer's disease (AD) is one of the most prominent neurodegenerative disorders. The aim of this study is to analyze the magnetoencephalogram (MEG) background activity in AD patients using sample entropy (SampEn) and multiscale entropy (MSE). The former quantifies the signal regularity, while the latter is a complexity measure. These concepts, irregularity and complexity, are linked although the relationship is not straightforward. Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 20 patients with probable AD and 21 control subjects. Our results show that MEG recordings are less complex and more regular in AD patients than in control subjects. Significant differences between both groups were found in some MEG channels with both methods (P <0.01, Student's t-test with Bonferroni's correction). Using receiver operating characteristic curves, accuracies of 75.6% with SampEn and of 87.8% with MSE were reached. Our findings show the usefulness of these entropy measures to increase our insight into AD.

Original language	English
Title of host publication	2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16
Place of Publication	NEW YORK
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	6184-6187
Number of pages	4
ISBN (Print)	978-1-4244-0787-3
Publication status	Published - 2007
Event	29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Lyon, France Duration: 22 Aug 2007 → 26 Aug 2007

Publication series

Name	PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY
Publisher	IEEE
ISSN (Print)	1094-687X

Conference

Conference	29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Country/Territory	France
City	Lyon
Period	22/08/07 → 26/08/07

Keywords

EEG BACKGROUND ACTIVITY
COMPLEXITY

Cite this

Gomez, C., Hornero, R., Abasolo, D., Fernandez, A., & Escudero, J. (2007). Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies. In 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16 (pp. 6184-6187). (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). Institute of Electrical and Electronics Engineers (IEEE).

Gomez, Carlos ; Hornero, Roberto ; Abasolo, Daniel et al. / Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies. 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. NEW YORK : Institute of Electrical and Electronics Engineers (IEEE), 2007. pp. 6184-6187 (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY).

@inproceedings{730ae66b41ce4bbab2daa47bd4187502,

title = "Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies",

abstract = "Alzheimer's disease (AD) is one of the most prominent neurodegenerative disorders. The aim of this study is to analyze the magnetoencephalogram (MEG) background activity in AD patients using sample entropy (SampEn) and multiscale entropy (MSE). The former quantifies the signal regularity, while the latter is a complexity measure. These concepts, irregularity and complexity, are linked although the relationship is not straightforward. Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 20 patients with probable AD and 21 control subjects. Our results show that MEG recordings are less complex and more regular in AD patients than in control subjects. Significant differences between both groups were found in some MEG channels with both methods (P <0.01, Student's t-test with Bonferroni's correction). Using receiver operating characteristic curves, accuracies of 75.6% with SampEn and of 87.8% with MSE were reached. Our findings show the usefulness of these entropy measures to increase our insight into AD.",

keywords = "EEG BACKGROUND ACTIVITY, COMPLEXITY",

author = "Carlos Gomez and Roberto Hornero and Daniel Abasolo and Alberto Fernandez and Javier Escudero",

year = "2007",

language = "English",

isbn = "978-1-4244-0787-3",

series = "PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY",

publisher = "Institute of Electrical and Electronics Engineers (IEEE)",

pages = "6184--6187",

booktitle = "2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16",

address = "United States",

note = "29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society ; Conference date: 22-08-2007 Through 26-08-2007",

}

Gomez, C, Hornero, R, Abasolo, D, Fernandez, A & Escudero, J 2007, Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies. in 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, Institute of Electrical and Electronics Engineers (IEEE), NEW YORK, pp. 6184-6187, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Lyon, France, 22/08/07.

Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies. / Gomez, Carlos; Hornero, Roberto; Abasolo, Daniel et al.

2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. NEW YORK : Institute of Electrical and Electronics Engineers (IEEE), 2007. p. 6184-6187 (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies

AU - Gomez, Carlos

AU - Hornero, Roberto

AU - Abasolo, Daniel

AU - Fernandez, Alberto

AU - Escudero, Javier

PY - 2007

Y1 - 2007

N2 - Alzheimer's disease (AD) is one of the most prominent neurodegenerative disorders. The aim of this study is to analyze the magnetoencephalogram (MEG) background activity in AD patients using sample entropy (SampEn) and multiscale entropy (MSE). The former quantifies the signal regularity, while the latter is a complexity measure. These concepts, irregularity and complexity, are linked although the relationship is not straightforward. Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 20 patients with probable AD and 21 control subjects. Our results show that MEG recordings are less complex and more regular in AD patients than in control subjects. Significant differences between both groups were found in some MEG channels with both methods (P <0.01, Student's t-test with Bonferroni's correction). Using receiver operating characteristic curves, accuracies of 75.6% with SampEn and of 87.8% with MSE were reached. Our findings show the usefulness of these entropy measures to increase our insight into AD.

AB - Alzheimer's disease (AD) is one of the most prominent neurodegenerative disorders. The aim of this study is to analyze the magnetoencephalogram (MEG) background activity in AD patients using sample entropy (SampEn) and multiscale entropy (MSE). The former quantifies the signal regularity, while the latter is a complexity measure. These concepts, irregularity and complexity, are linked although the relationship is not straightforward. Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 20 patients with probable AD and 21 control subjects. Our results show that MEG recordings are less complex and more regular in AD patients than in control subjects. Significant differences between both groups were found in some MEG channels with both methods (P <0.01, Student's t-test with Bonferroni's correction). Using receiver operating characteristic curves, accuracies of 75.6% with SampEn and of 87.8% with MSE were reached. Our findings show the usefulness of these entropy measures to increase our insight into AD.

KW - EEG BACKGROUND ACTIVITY

KW - COMPLEXITY

M3 - Conference contribution

SN - 978-1-4244-0787-3

T3 - PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY

SP - 6184

EP - 6187

BT - 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16

PB - Institute of Electrical and Electronics Engineers (IEEE)

CY - NEW YORK

T2 - 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Y2 - 22 August 2007 through 26 August 2007

ER -

Gomez C, Hornero R, Abasolo D, Fernandez A, Escudero J. Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies. In 2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16. NEW YORK: Institute of Electrical and Electronics Engineers (IEEE). 2007. p. 6184-6187. (PROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY).

Analysis of MEG recordings from Alzheimer's disease patients with sample and multiscale entropies

Abstract

Publication series

Conference

Keywords

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