Analysis of part of the chicken Rfp-Y region reveals two novel lectin genes, the first complete genomic sequence of a class I α-chain gene, a truncated class II β-chain gene, and a large CR1 repeat

S Rogers, I Shaw, N Ross, V. Nair, Lisa Rothwell, J. Kaufman, Pete Kaiser

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The Rfp-Y region lies on the same microchromosome as the B-F/B-L region of the B complex, yet in contrast to the latter it is poorly characterised. To date it has been shown to contain at least two class I alpha-chain ( Y-F) genes, a class II B-chain gene and a C-type lectin-like gene. We describe the sequencing and analysis of some 20 kb of the Rfp-Y region, and identify several new genes. These include two novel C-type lectin-like genes ( Y-Lec1 and Y-Lec2) that differ strongly from the previously described C-type lectin-like gene found in the Rfp-Y region. We describe a complete genomic sequence of a class I alpha-chain ( Y-F) gene and its promoter from the Rfp-Y region. The predicted cDNA from this gene has high homology to the previously reported Y-F cDNAs. The promoter contains an altered enhancer A element. This portion of the Rfp-Y region also contains a truncated class II B-chain ( Y-LB) gene, as well as a large chicken repeat 1 (CR1) element.
Original languageEnglish
Pages (from-to)100-108
Number of pages9
JournalImmunogenetics
Volume55
Issue number2
DOIs
Publication statusPublished - 2003

Keywords / Materials (for Non-textual outputs)

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chickens/genetics
  • Chickens/immunology
  • Enhancer Elements, Genetic
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Lectins/genetics
  • Molecular Sequence Data
  • Phylogeny

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