Analysis of spontaneous MEG activity in patients with Alzheimer's disease using spectral entropies

Jesus Poza*, Roberto Hornero, Daniel Abasolo, Alberto Fernandez, Javier Escudero

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this study was to explore the ability of several spectral entropies to discriminate between spontaneous magnetoencephalographic (MEG) oscillations from 20 Alzheimer's disease (AD) patients and 21 controls. Hence, the relative spectral power (RSP) in classical frequency bands was calculated from the averaged power spectral density. Given the fact that the RSP can be viewed as a probability distribution function, the Shannon spectral entropy, Tsallis spectral entropy, generalized escort-Tsallis spectral entropy and Renyi spectral entropy were calculated from the RSP. Significant differences for each parameter were assessed with Mann-Whitney U test, whereas classification performance was studied using binary logistic regression. Results revealed an increase in the RSP of control subjects at beta and gamma bands, while AD patients showed an increase in the RSP values at delta and theta bands. Entropies obtained statistically significant lower values for AD patients than for controls. This issue suggests a significant decrease in irregularity of AD patients' MEG activity.

Original languageEnglish
Title of host publication2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16
Place of PublicationNEW YORK
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages6180-6183
Number of pages4
ISBN (Print)978-1-4244-0787-3
Publication statusPublished - 2007
Event29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Lyon, France
Duration: 22 Aug 200726 Aug 2007

Publication series

NamePROCEEDINGS OF ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY
PublisherIEEE
ISSN (Print)1094-687X

Conference

Conference29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Country/TerritoryFrance
CityLyon
Period22/08/0726/08/07

Keywords

  • MILD COGNITIVE IMPAIRMENT
  • EEG
  • OSCILLATIONS
  • DYNAMICS

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