Analysis of submicron-sized niflumic acid crystals prepared by electrospray crystallization

Rita Ambrus, Norbert Radacsi, Timea Szunyogh, Antoine E. D. M. van der Heijden, Joop H. ter Horst, Piroska Szabo-Revesz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Interest in submicron-sized drug particles has emerged from both laboratory and industrial perspectives in the last decade. Production of crystals in the nano size scale offers a novel way to particles for drug formulation solving formulation problems of drugs with low solubility in class II of the Biopharmaceutical Classification System. In this work niflumic acid nanoparticles with a size range of 200-800 nm were produced by the novel crystallization method, electrospray crystallization. Their properties were compared to those from evaporative and anti-solvent crystallizations, using the same organic solvent, acetone. There is a remarkable difference in the product crystal size depending on the applied methods. The size and morphology were analyzed by scanning electron microscopy and laser diffraction. The structure of the samples was investigated using differential scanning calorimetry, Fourier-transformed infrared spectroscopy and X-ray powder diffraction. The particles produced using electrospray crystallization process were probably changing from amorphous to crystalline state after the procedure. (c) 2012 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Pharmaceutical and Biomedical analysis
Volume76
Early online date10 Dec 2012
DOIs
Publication statusPublished - 25 Mar 2013

Keywords

  • Nanoparticles
  • Electrospray crystallization
  • Anti-solvent crystallization
  • Solvent evaporation
  • Niflumic acid
  • Physico-chemical analysis
  • POORLY SOLUBLE DRUGS
  • NANOPARTICLES
  • NANOSUSPENSIONS
  • DISPERSION
  • INCLUSION

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