Analysis of Wnt pathway genes during ex vivo expansion and neutrophil differentiation of umbilical-cord-blood-derived CD34 cells

R C J Gallagher, O Tura-Ceide, M Turner, R Barclay

Research output: Contribution to journalArticlepeer-review

Abstract

Previous work has shown that optimal ex vivo expansion and differentiation of CD34(+) progenitor cells into neutrophils is by addition of Flt3-L, SCF and G-CSF. Here we report that a variety of genes involved in the WNT pathway are transcriptionally active in both undifferentiated and differentiated umbilical cord blood CD34(+) cells, however statistically significant changes in gene expression are not always consistent across UCB samples.
Original languageEnglish
Pages (from-to)e290-4
Number of pages5
JournalVox Sanguinis
Volume98
Issue number3
DOIs
Publication statusPublished - 2010

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