Analytic result variation for high-sensitivity cardiac troponin: Interpretation and consequences

Peter A. Kavsak, Lorna Clark, Saranya Arnoldo, Amy Lou, Jennifer L. Shea, Shaun Eintracht, Andrew W. Lyon, Vipin Bhayana, Laurel Thorlacius, Joshua E. Raizman, Albert K.y. Tsui, Rose Djiana, Michael Chen, Yun Huang, Ronald A. Booth, Chris Mccudden, Joël Lavoie, Daniel R. Beriault, David W. Blank, Angela W.s. FungBarry Hoffman, Jennifer Taher, Julie St-Cyr, Paul M. Yip, Emilie P. Belley-Cote, Beth L. Abramson, Bjug Borgundvaag, Steven M. Friedman, Susanna Mak, Jesse Mclaren, Brian Steinhart, Jacob A. Udell, Harindra C. Wijeysundera, Paul Atkinson, Samuel G. Campbell, Kavish Chandra, Jafna L. Cox, Sharon Mulvagh, Ata-ur-rehman Quraishi, Annabel Chen-Tournoux, Gregory Clark, Eli Segal, Neville Suskin, Amer M. Johri, Marco L.a. Sivilotti, Habibat Garuba, Venkatesh Thiruganasambandamoorthy, Simon Robinson, Frank Scheuermeyer, Karin H. Humphries, Martin Than, John W. Pickering, Andrew Worster, Nicholas L. Mills, P.j. Devereaux, Allan S. Jaffe

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In a CODE-MI sub-study, six troponin assays were evaluated over 12 months using 3-samples (normal, female and male 99th-percentile levels; n=2,142 results from 67 instruments). Mean differences varied per assay with maximum values being ±4, ±8 and ±9 ng/L at the normal and sex-specific 99th-percentiles, respectively. A pragmatic approach, combining all assays, established maximum differences of ±3 ng/L or ±30%.
Original languageEnglish
JournalCanadian journal of cardiology
Early online date22 Apr 2023
DOIs
Publication statusE-pub ahead of print - 22 Apr 2023

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