Analytical study of an exclusive genetic switch

J. Venegas-Ortiz, Martin R. Evans

Research output: Contribution to journalArticlepeer-review

Abstract

The nonequilibrium stationary state of an exclusive genetic switch is considered. The model comprises two competing species and a single binding site which, when bound to by a protein of one species, causes the other species to be repressed. The model may be thought of as a minimal model of the power struggle between two competing parties. Exact solutions are given for the limits of vanishing binding/unbinding rates and infinite binding/unbinding rates. A mean field theory is introduced which is exact in the limit of vanishing binding/unbinding rates. The mean field theory and numerical simulations reveal that generically bistability occurs. An exact perturbative solution which in principle allows the nonequilibrium stationary state to be computed is also developed and computed to first and second order.

Original languageEnglish
Article number355001
Pages (from-to)-
Number of pages27
JournalJournal of physics a-Mathematical and theoretical
Volume44
Issue number35
DOIs
Publication statusPublished - 2 Sep 2011

Keywords

  • SPONTANEOUS SYMMETRY-BREAKING
  • ESCHERICHIA-COLI
  • EXPRESSION

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