The World Allergy Organization (WAO) defines anaphylaxis as follows: “allergic anaphylaxis” is immunologically mediated and involves IgE, IgG and immune complexes, whereas “non-allergic anaphylaxis” refers to anaphylaxis from whatever non-immunologic cause and replaces the term “anaphylactoid”. Anaphylaxis, as used in this chapter, includes both allergic and non-allergic anaphylaxis. Although there are separate pathophysiologic mechanisms involved in anaphylaxis, the lack of a consensus definition results in confusion as to how it should be treated, and especially when epinephrine should be administered. Likewise, there are no prospective controlled studies which indicate when epinephrine should be administered and if and when antihistamines and a glucocorticosteroid should be administered.
|Title of host publication||World Allergy Organization White Book on Allergy|
|Editors||Ruby Pawankar, Stephen Holgate, G. Walter Canonica, Richard F Lockey, Michael S Blaiss|
|Publisher||World Allergy Organization|
|ISBN (Electronic)||0615929168 , 978-0-615-92916-3|
|ISBN (Print)||061592915X , 978-0-615-92915-6|
|Publication status||Published - 2013|