In the presence of excess Bu2BOTf to promote anti-selectivity, an asymmetric aldol reaction with a homochiral terpenoid-derived 1,3-oxazin-2-one as the chiral control element results unexpectedly in ring cleavage by an intramolecular process to form a N-substituted tetrahydro-1,3-oxazine-2,4-dione in virtually quantitative yield. (C) 1997 Elsevier Science Ltd.
|Title of host publication||Anatomy Ontologies for Bioinformatics: Principles and Practice|
|Number of pages||15|
|Publication status||Published - 2008|