Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

Marta Pereira Verdugo; Victoria E. Mullin; Amelie Scheu; Valeria Mattiangeli; Kevin G. Daly; Pierpaolo Maisano Delser; Andrew J. Hare; Joachim Burger; Matthew J. Collins; Ron Kehati; Paula Hesse; Deirdre Fulton; Eberhard W. Sauer; Fatemeh A. Mohaseb; Hossein Davoudi; Roya Khazaeli; Johanna Lhuillier; Claude Rapin; Saeed Ebrahimi; Mutalib Khasanov; S. M. Farhad Vahidi; David E. MacHugh; Okan Ertuğrul; Chaido Koukouli-Chrysanthaki; Adamantios Sampson; George Kazantzis; Ioannis Kontopoulos; Jelena Bulatovic; Ivana Stojanović; Abdesalam Mikdad; Norbert Benecke; Jörg Linstädter; Mikhail Sablin; Robin Bendrey; Lionel Gourichon; Benjamin S. Arbuckle; Marjan Mashkour; David Orton; Liora Kolska Horwitz; Matthew D. Teasdale; Daniel G. Bradley

doi:10.1126/science.aav1002

Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

Marta Pereira Verdugo, Victoria E. Mullin, Amelie Scheu, Valeria Mattiangeli, Kevin G. Daly, Pierpaolo Maisano Delser, Andrew J. Hare, Joachim Burger, Matthew J. Collins, Ron Kehati, Paula Hesse, Deirdre Fulton, Eberhard W. Sauer, Fatemeh A. Mohaseb, Hossein Davoudi, Roya Khazaeli, Johanna Lhuillier, Claude Rapin, Saeed Ebrahimi, Mutalib KhasanovS. M. Farhad Vahidi, David E. MacHugh, Okan Ertuğrul, Chaido Koukouli-Chrysanthaki, Adamantios Sampson, George Kazantzis, Ioannis Kontopoulos, Jelena Bulatovic, Ivana Stojanović, Abdesalam Mikdad, Norbert Benecke, Jörg Linstädter, Mikhail Sablin, Robin Bendrey, Lionel Gourichon, Benjamin S. Arbuckle, Marjan Mashkour, David Orton, Liora Kolska Horwitz, Matthew D. Teasdale, Daniel G. Bradley

Research output: Contribution to journal › Article › peer-review

Abstract

Cattle were domesticated ∼10,000 years ago, but analysis of modern breeds has not elucidated their origins. Verdugo et al. performed genome-wide analysis of 67 ancient Near Eastern Bos taurus DNA samples. Several populations of ancient aurochs were progenitors of domestic cows. These genetic lineages mixed ∼4000 years ago in a region around the Indus Valley. Interestingly, mitochondrial analysis indicated that genetic material likely derived from arid-adapted Bos indicus (zebu) bulls was introduced by introgression.Science, this issue p. 173Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in modern populations. Comparisons of genomes of early domestic cattle to their aurochs progenitors identify diverse origins with separate introgressions of wild stock. A later region-wide Bronze Age shift indicates rapid and widespread introgression of zebu, Bos indicus, from the Indus Valley. This process was likely stimulated at the onset of the current geological age, ~4.2 thousand years ago, by a widespread multicentury drought. In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgression was male-driven, suggesting that selection of arid-adapted zebu bulls enhanced herd survival. This human-mediated migration of zebu-derived genetics has continued through millennia, altering tropical herding on each continent.

Original language	English
Journal	Science
Volume	365
Issue number	6449
DOIs	https://doi.org/10.1126/science.aav1002
Publication status	Published - 12 Jul 2019

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PereiraVerdugoEtal2019SAncientCattleGenomics
This is the accepted version of the following article: Verdugo, MP etal. 2019, 'Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent' Science, vol. 365, no. 6449. DOI: 10.1126/science.aav1002, which has been published in final form at https://science.sciencemag.org/content/365/6449/173.abstract.
Accepted author manuscript, 8.63 MB

http://science.sciencemag.org/content/365/6449/173.abstract

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Verdugo, M. P., Mullin, V. E., Scheu, A., Mattiangeli, V., Daly, K. G., Maisano Delser, P., Hare, A. J., Burger, J., Collins, M. J., Kehati, R., Hesse, P., Fulton, D., Sauer, E. W., Mohaseb, F. A., Davoudi, H., Khazaeli, R., Lhuillier, J., Rapin, C., Ebrahimi, S., ... Bradley, D. G. (2019). Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent. Science, 365(6449). https://doi.org/10.1126/science.aav1002

@article{ad02b6775bc74d98a540676e875a12b4,

title = "Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent",

abstract = "Cattle were domesticated ∼10,000 years ago, but analysis of modern breeds has not elucidated their origins. Verdugo et al. performed genome-wide analysis of 67 ancient Near Eastern Bos taurus DNA samples. Several populations of ancient aurochs were progenitors of domestic cows. These genetic lineages mixed ∼4000 years ago in a region around the Indus Valley. Interestingly, mitochondrial analysis indicated that genetic material likely derived from arid-adapted Bos indicus (zebu) bulls was introduced by introgression.Science, this issue p. 173Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in modern populations. Comparisons of genomes of early domestic cattle to their aurochs progenitors identify diverse origins with separate introgressions of wild stock. A later region-wide Bronze Age shift indicates rapid and widespread introgression of zebu, Bos indicus, from the Indus Valley. This process was likely stimulated at the onset of the current geological age, ~4.2 thousand years ago, by a widespread multicentury drought. In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgression was male-driven, suggesting that selection of arid-adapted zebu bulls enhanced herd survival. This human-mediated migration of zebu-derived genetics has continued through millennia, altering tropical herding on each continent.",

author = "Verdugo, {Marta Pereira} and Mullin, {Victoria E.} and Amelie Scheu and Valeria Mattiangeli and Daly, {Kevin G.} and {Maisano Delser}, Pierpaolo and Hare, {Andrew J.} and Joachim Burger and Collins, {Matthew J.} and Ron Kehati and Paula Hesse and Deirdre Fulton and Sauer, {Eberhard W.} and Mohaseb, {Fatemeh A.} and Hossein Davoudi and Roya Khazaeli and Johanna Lhuillier and Claude Rapin and Saeed Ebrahimi and Mutalib Khasanov and Vahidi, {S. M. Farhad} and MacHugh, {David E.} and Okan Ertuğrul and Chaido Koukouli-Chrysanthaki and Adamantios Sampson and George Kazantzis and Ioannis Kontopoulos and Jelena Bulatovic and Ivana Stojanovi{\'c} and Abdesalam Mikdad and Norbert Benecke and J{\"o}rg Linst{\"a}dter and Mikhail Sablin and Robin Bendrey and Lionel Gourichon and Arbuckle, {Benjamin S.} and Marjan Mashkour and David Orton and Horwitz, {Liora Kolska} and Teasdale, {Matthew D.} and Bradley, {Daniel G.}",

year = "2019",

month = jul,

day = "12",

doi = "10.1126/science.aav1002",

language = "English",

volume = "365",

journal = "Science",

issn = "0036-8075",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "6449",

}

Verdugo, MP, Mullin, VE, Scheu, A, Mattiangeli, V, Daly, KG, Maisano Delser, P, Hare, AJ, Burger, J, Collins, MJ, Kehati, R, Hesse, P, Fulton, D, Sauer, EW, Mohaseb, FA, Davoudi, H, Khazaeli, R, Lhuillier, J, Rapin, C, Ebrahimi, S, Khasanov, M, Vahidi, SMF, MacHugh, DE, Ertuğrul, O, Koukouli-Chrysanthaki, C, Sampson, A, Kazantzis, G, Kontopoulos, I, Bulatovic, J, Stojanović, I, Mikdad, A, Benecke, N, Linstädter, J, Sablin, M, Bendrey, R, Gourichon, L, Arbuckle, BS, Mashkour, M, Orton, D, Horwitz, LK, Teasdale, MD & Bradley, DG 2019, 'Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent', Science, vol. 365, no. 6449. https://doi.org/10.1126/science.aav1002

TY - JOUR

T1 - Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

AU - Verdugo, Marta Pereira

AU - Mullin, Victoria E.

AU - Scheu, Amelie

AU - Mattiangeli, Valeria

AU - Daly, Kevin G.

AU - Maisano Delser, Pierpaolo

AU - Hare, Andrew J.

AU - Burger, Joachim

AU - Collins, Matthew J.

AU - Kehati, Ron

AU - Hesse, Paula

AU - Fulton, Deirdre

AU - Sauer, Eberhard W.

AU - Mohaseb, Fatemeh A.

AU - Davoudi, Hossein

AU - Khazaeli, Roya

AU - Lhuillier, Johanna

AU - Rapin, Claude

AU - Ebrahimi, Saeed

AU - Khasanov, Mutalib

AU - Vahidi, S. M. Farhad

AU - MacHugh, David E.

AU - Ertuğrul, Okan

AU - Koukouli-Chrysanthaki, Chaido

AU - Sampson, Adamantios

AU - Kazantzis, George

AU - Kontopoulos, Ioannis

AU - Bulatovic, Jelena

AU - Stojanović, Ivana

AU - Mikdad, Abdesalam

AU - Benecke, Norbert

AU - Linstädter, Jörg

AU - Sablin, Mikhail

AU - Bendrey, Robin

AU - Gourichon, Lionel

AU - Arbuckle, Benjamin S.

AU - Mashkour, Marjan

AU - Orton, David

AU - Horwitz, Liora Kolska

AU - Teasdale, Matthew D.

AU - Bradley, Daniel G.

PY - 2019/7/12

Y1 - 2019/7/12

N2 - Cattle were domesticated ∼10,000 years ago, but analysis of modern breeds has not elucidated their origins. Verdugo et al. performed genome-wide analysis of 67 ancient Near Eastern Bos taurus DNA samples. Several populations of ancient aurochs were progenitors of domestic cows. These genetic lineages mixed ∼4000 years ago in a region around the Indus Valley. Interestingly, mitochondrial analysis indicated that genetic material likely derived from arid-adapted Bos indicus (zebu) bulls was introduced by introgression.Science, this issue p. 173Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in modern populations. Comparisons of genomes of early domestic cattle to their aurochs progenitors identify diverse origins with separate introgressions of wild stock. A later region-wide Bronze Age shift indicates rapid and widespread introgression of zebu, Bos indicus, from the Indus Valley. This process was likely stimulated at the onset of the current geological age, ~4.2 thousand years ago, by a widespread multicentury drought. In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgression was male-driven, suggesting that selection of arid-adapted zebu bulls enhanced herd survival. This human-mediated migration of zebu-derived genetics has continued through millennia, altering tropical herding on each continent.

AB - Cattle were domesticated ∼10,000 years ago, but analysis of modern breeds has not elucidated their origins. Verdugo et al. performed genome-wide analysis of 67 ancient Near Eastern Bos taurus DNA samples. Several populations of ancient aurochs were progenitors of domestic cows. These genetic lineages mixed ∼4000 years ago in a region around the Indus Valley. Interestingly, mitochondrial analysis indicated that genetic material likely derived from arid-adapted Bos indicus (zebu) bulls was introduced by introgression.Science, this issue p. 173Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in modern populations. Comparisons of genomes of early domestic cattle to their aurochs progenitors identify diverse origins with separate introgressions of wild stock. A later region-wide Bronze Age shift indicates rapid and widespread introgression of zebu, Bos indicus, from the Indus Valley. This process was likely stimulated at the onset of the current geological age, ~4.2 thousand years ago, by a widespread multicentury drought. In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgression was male-driven, suggesting that selection of arid-adapted zebu bulls enhanced herd survival. This human-mediated migration of zebu-derived genetics has continued through millennia, altering tropical herding on each continent.

U2 - 10.1126/science.aav1002

DO - 10.1126/science.aav1002

M3 - Article

VL - 365

JO - Science

JF - Science

SN - 0036-8075

IS - 6449

ER -

Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent

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