Androgens and endometrium: New insights and new targets

Ioannis Simitsidellis; Philippa T K Saunders; Douglas A Gibson

doi:10.1016/j.mce.2017.09.022

Androgens and endometrium: New insights and new targets

Ioannis Simitsidellis, Philippa T K Saunders, Douglas A Gibson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Androgens are synthesised in both the ovary and adrenals in women and play an important role in the regulation of female fertility, as well as in the aetiology of disorders such as polycystic ovarian syndrome, endometriosis and endometrial cancer. The endometrium is an androgen target tissue and the impact of AR-mediated effects has been studied using human endometrial tissue samples and rodent models. In this review we highlight recent evidence that endometrial androgen biosynthesis and intracrine action is important in preparation of a tissue microenvironment that can support implantation and establishment of pregnancy. The impact of androgens on endometrial cell proliferation, in repair of the endometrial wound at the time of menstruation and in endometrial disorders is discussed. Future directions for research focused on AR function as a therapeutic target are considered.

Original language	English
Journal	Molecular and Cellular Endocrinology
Volume	465
Early online date	15 Sept 2017
DOIs	https://doi.org/10.1016/j.mce.2017.09.022
Publication status	Published - 15 Apr 2018

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Journal Article
Review

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10.1016/j.mce.2017.09.022

Impact of sex steroids on immune and vascular cell function in the reproductive system
Saunders, P.
MRC
1/10/11 → 31/03/17
Project: Research

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title = "Androgens and endometrium: New insights and new targets",

abstract = "Androgens are synthesised in both the ovary and adrenals in women and play an important role in the regulation of female fertility, as well as in the aetiology of disorders such as polycystic ovarian syndrome, endometriosis and endometrial cancer. The endometrium is an androgen target tissue and the impact of AR-mediated effects has been studied using human endometrial tissue samples and rodent models. In this review we highlight recent evidence that endometrial androgen biosynthesis and intracrine action is important in preparation of a tissue microenvironment that can support implantation and establishment of pregnancy. The impact of androgens on endometrial cell proliferation, in repair of the endometrial wound at the time of menstruation and in endometrial disorders is discussed. Future directions for research focused on AR function as a therapeutic target are considered.",

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author = "Ioannis Simitsidellis and Saunders, {Philippa T K} and Gibson, {Douglas A}",

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year = "2018",

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doi = "10.1016/j.mce.2017.09.022",

language = "English",

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T2 - New insights and new targets

AU - Simitsidellis, Ioannis

AU - Saunders, Philippa T K

AU - Gibson, Douglas A

PY - 2018/4/15

Y1 - 2018/4/15

N2 - Androgens are synthesised in both the ovary and adrenals in women and play an important role in the regulation of female fertility, as well as in the aetiology of disorders such as polycystic ovarian syndrome, endometriosis and endometrial cancer. The endometrium is an androgen target tissue and the impact of AR-mediated effects has been studied using human endometrial tissue samples and rodent models. In this review we highlight recent evidence that endometrial androgen biosynthesis and intracrine action is important in preparation of a tissue microenvironment that can support implantation and establishment of pregnancy. The impact of androgens on endometrial cell proliferation, in repair of the endometrial wound at the time of menstruation and in endometrial disorders is discussed. Future directions for research focused on AR function as a therapeutic target are considered.

AB - Androgens are synthesised in both the ovary and adrenals in women and play an important role in the regulation of female fertility, as well as in the aetiology of disorders such as polycystic ovarian syndrome, endometriosis and endometrial cancer. The endometrium is an androgen target tissue and the impact of AR-mediated effects has been studied using human endometrial tissue samples and rodent models. In this review we highlight recent evidence that endometrial androgen biosynthesis and intracrine action is important in preparation of a tissue microenvironment that can support implantation and establishment of pregnancy. The impact of androgens on endometrial cell proliferation, in repair of the endometrial wound at the time of menstruation and in endometrial disorders is discussed. Future directions for research focused on AR function as a therapeutic target are considered.

KW - Journal Article

KW - Review

U2 - 10.1016/j.mce.2017.09.022

DO - 10.1016/j.mce.2017.09.022

M3 - Article

C2 - 28919297

SN - 0303-7207

VL - 465

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

Androgens and endometrium: New insights and new targets

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Impact of sex steroids on immune and vascular cell function in the reproductive system

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