Aneuploidy as a mechanism of adaptation to telomerase insufficiency

Caroline Millet, Svetlana Makovets

Research output: Contribution to journalArticlepeer-review

Abstract

Cells’ survival is determined by their ability to adapt to constantly changing environment. Adaptation responses involve global changes in transcription, translation, and posttranslational modifications of proteins. In recent years, karyotype changes in adapting populations of single cell organisms have been reported in a number of studies. More recently, we have described aneuploidy
as an adaptation mechanism used by populations of budding yeast Saccharomyces cerevisiae to survive telomerase insufficiency induced by elevated growth temperature. Genetic evidence suggests that telomerase insufficiency is caused by decreased levels of the telomerase catalytic subunit Est2. Here, we present experiments arguing that the underlying cause of this phenomenon may be within the telomerase RNA TLC1: changes in the expression of TLC1 as well as mutations in the TLC1 template region affect telomere length equilibrium and the temperature threshold for
the induction of telomerase insufficiency. We discuss what lies at the root of telomerase insufficiency, how cell populations overcome it through aneuploidy and whether reversible aneuploidy could be an adaptation mechanism for a variety of environmental stresses.
Original languageEnglish
Pages (from-to)557-64
Number of pages8
JournalCurrent Genetics
Volume62
Issue number3
Early online date12 Jan 2016
DOIs
Publication statusPublished - Aug 2016

Keywords

  • Adaptation
  • Aneuploidy
  • Telomerase
  • Telomerase insufficiency
  • Telomeres
  • Yeast

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