Aneuploidy in cancer: Lessons from acute lymphoblastic leukemia

Oscar Molina, Maria Alba Abad, Francesc Solé, Pablo Menéndez

Research output: Contribution to journalArticlepeer-review

Abstract

Aneuploidy, the gain or loss of chromosomes in a cell, is a hallmark of cancer. Although our understanding of the contribution of aneuploidy to cancer initiation and progression is incomplete, significant progress has been made in uncovering the cellular consequences of aneuploidy and how aneuploid cancer cells self adapt to promote tumorigenesis. Aneuploidy is physiologically associated with significant cellular stress but, paradoxically, it favors tumor progression. Although more common in solid tumors, different forms of aneuploidy represent the initiating oncogenic lesion in patients with B cell acute lymphoblastic leukemia (B-ALL),making B-ALL an excellent model for studying the role of aneuploidy in tumorigenesis. We review the molecular mechanisms underlying aneuploidy and discuss its contributions to B-ALL initiation and progression.
Original languageEnglish
Pages (from-to)37-47
Number of pages11
JournalTrends in Cancer
Volume7
Issue number1
Early online date17 Sep 2020
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • aneuploidy
  • mitosis
  • chromosome segregation
  • hematological neoplasms
  • B cell acute lymphoblastic leukemia

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