Angiotensin II augments sympathetically induced venoconstriction in man

N Benjamin, J. G. Collier, David J Webb

Research output: Contribution to journalArticlepeer-review

Abstract

1. The constriction produced by a single deep breath was measured simultaneously in two adjacent hand veins in normal volunteers. One vein was infused with angiotensin II (ANG II) while the other acted as a control. 2. At a dose lower than that required to produce direct venous constriction (1 pmol/min), ANG II significantly augmented the constriction caused by a deep breath in eight subjects (P less than 0.01). The same dose had no effect on the venoconstriction caused by infused noradrenaline (NA) in a further six subjects. 3. It is concluded that ANG II at low doses may cause venoconstriction indirectly by augmenting sympathetically induced venous tone via a presynaptic mechanism. This observation may help to explain the apparent venodilating property of angiotensin-converting enzyme inhibitors in clinical situations where the renin-angiotensin system is stimulated.
Original languageEnglish
Pages (from-to)337–340
JournalClinical science
Volume75
Issue number4
DOIs
Publication statusPublished - 1 Oct 1988

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