Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition

J M Barnes, N M Barnes, B Costall, Z P Horovitz, J W Ironside, R J Naylor, T J Williams

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Angiotensin II was shown to inhibit potassium-stimulated release of [3H]acetylcholine from slices of fresh human temporal cortex, obtained at surgery, and subsequently loaded with [3H]choline for the biochemical analyses. The inhibitory effect of angiotensin II was antagonised by the specific angiotensin II receptor antagonist [1-sarcosine, 8-threonine]-angiotensin II. High affinity binding sites were identified in the human temporal cortex using [125I]angiotensin II, and may provide the functional site of action of angiotensin II to modify [3H]acetylcholine release.

Original languageEnglish
Pages (from-to)341-3
Number of pages3
JournalBrain Research
Volume507
Issue number2
Publication statusPublished - 22 Jan 1990

Keywords / Materials (for Non-textual outputs)

  • Acetylcholine
  • Angiotensin II
  • Angiotensin Receptor Antagonists
  • Cognition
  • Female
  • Humans
  • In Vitro Techniques
  • Middle Aged
  • Receptors, Angiotensin
  • Temporal Lobe

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