Abstract / Description of output
Angiotensin II was shown to inhibit potassium-stimulated release of [3H]acetylcholine from slices of fresh human temporal cortex, obtained at surgery, and subsequently loaded with [3H]choline for the biochemical analyses. The inhibitory effect of angiotensin II was antagonised by the specific angiotensin II receptor antagonist [1-sarcosine, 8-threonine]-angiotensin II. High affinity binding sites were identified in the human temporal cortex using [125I]angiotensin II, and may provide the functional site of action of angiotensin II to modify [3H]acetylcholine release.
Original language | English |
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Pages (from-to) | 341-3 |
Number of pages | 3 |
Journal | Brain Research |
Volume | 507 |
Issue number | 2 |
Publication status | Published - 22 Jan 1990 |
Keywords / Materials (for Non-textual outputs)
- Acetylcholine
- Angiotensin II
- Angiotensin Receptor Antagonists
- Cognition
- Female
- Humans
- In Vitro Techniques
- Middle Aged
- Receptors, Angiotensin
- Temporal Lobe