Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition

J M Barnes; N M Barnes; B Costall; Z P Horovitz; J W Ironside; R J Naylor; T J Williams

Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition

J M Barnes, N M Barnes, B Costall, Z P Horovitz, J W Ironside, R J Naylor, T J Williams

Research output: Contribution to journal › Article › peer-review

Abstract

Angiotensin II was shown to inhibit potassium-stimulated release of [3H]acetylcholine from slices of fresh human temporal cortex, obtained at surgery, and subsequently loaded with [3H]choline for the biochemical analyses. The inhibitory effect of angiotensin II was antagonised by the specific angiotensin II receptor antagonist [1-sarcosine, 8-threonine]-angiotensin II. High affinity binding sites were identified in the human temporal cortex using [125I]angiotensin II, and may provide the functional site of action of angiotensin II to modify [3H]acetylcholine release.

Original language	English
Pages (from-to)	341-3
Number of pages	3
Journal	Brain Research
Volume	507
Issue number	2
Publication status	Published - 22 Jan 1990

Keywords / Materials (for Non-textual outputs)

Acetylcholine
Angiotensin II
Angiotensin Receptor Antagonists
Cognition
Female
Humans
In Vitro Techniques
Middle Aged
Receptors, Angiotensin
Temporal Lobe

Cite this

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title = "Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition",

abstract = "Angiotensin II was shown to inhibit potassium-stimulated release of [3H]acetylcholine from slices of fresh human temporal cortex, obtained at surgery, and subsequently loaded with [3H]choline for the biochemical analyses. The inhibitory effect of angiotensin II was antagonised by the specific angiotensin II receptor antagonist [1-sarcosine, 8-threonine]-angiotensin II. High affinity binding sites were identified in the human temporal cortex using [125I]angiotensin II, and may provide the functional site of action of angiotensin II to modify [3H]acetylcholine release.",

keywords = "Acetylcholine, Angiotensin II, Angiotensin Receptor Antagonists, Cognition, Female, Humans, In Vitro Techniques, Middle Aged, Receptors, Angiotensin, Temporal Lobe",

author = "Barnes, \{J M\} and Barnes, \{N M\} and B Costall and Horovitz, \{Z P\} and Ironside, \{J W\} and Naylor, \{R J\} and Williams, \{T J\}",

year = "1990",

month = jan,

day = "22",

language = "English",

volume = "507",

pages = "341--3",

journal = "Brain Research",

issn = "0006-8993",

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TY - JOUR

T1 - Angiotensin II inhibits acetylcholine release from human temporal cortex

T2 - implications for cognition

AU - Barnes, J M

AU - Barnes, N M

AU - Costall, B

AU - Horovitz, Z P

AU - Ironside, J W

AU - Naylor, R J

AU - Williams, T J

PY - 1990/1/22

Y1 - 1990/1/22

N2 - Angiotensin II was shown to inhibit potassium-stimulated release of [3H]acetylcholine from slices of fresh human temporal cortex, obtained at surgery, and subsequently loaded with [3H]choline for the biochemical analyses. The inhibitory effect of angiotensin II was antagonised by the specific angiotensin II receptor antagonist [1-sarcosine, 8-threonine]-angiotensin II. High affinity binding sites were identified in the human temporal cortex using [125I]angiotensin II, and may provide the functional site of action of angiotensin II to modify [3H]acetylcholine release.

AB - Angiotensin II was shown to inhibit potassium-stimulated release of [3H]acetylcholine from slices of fresh human temporal cortex, obtained at surgery, and subsequently loaded with [3H]choline for the biochemical analyses. The inhibitory effect of angiotensin II was antagonised by the specific angiotensin II receptor antagonist [1-sarcosine, 8-threonine]-angiotensin II. High affinity binding sites were identified in the human temporal cortex using [125I]angiotensin II, and may provide the functional site of action of angiotensin II to modify [3H]acetylcholine release.

KW - Acetylcholine

KW - Angiotensin II

KW - Angiotensin Receptor Antagonists

KW - Cognition

KW - Female

KW - Humans

KW - In Vitro Techniques

KW - Middle Aged

KW - Receptors, Angiotensin

KW - Temporal Lobe

M3 - Article

C2 - 2337775

SN - 0006-8993

VL - 507

SP - 341

EP - 343

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition

Abstract

Keywords / Materials (for Non-textual outputs)

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