Animal and Cell Models for type II diabetes and their use

Alan Hart (Inventor), Helena Edlund (Inventor), N Baeza (Inventor), A Apelqvist (Inventor)

Research output: Patent

Abstract / Description of output

A transgenic diabetes type II model laboratory animal is disclosed which comprises beta-cells expressing a dominant negative form (dnFGFR1c) of FGFR1c. Also disclosed is the use of the Ipf1/Pdx1 promoter for controlling expression of FGFR1c; beta-cells in which the expression of PC1/3 is down-regulated or absent or which are competent to express a dominant negative form (dnFGFR1c) of FGFR1c; mature beta-cells incompetent to express Glut2 or in which the processing of proinsulin is substantially impaired; a method of preventing or treating type II diabetes.
Original languageEnglish
Patent numberWO/2001/076361
Publication statusPublished - 18 Oct 2001


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