Animal models of airway inflammation and airway smooth muscle remodelling in asthma

Judith E Allen, Robert J Bischof, Herng-Yu Sucie Chang, Jeremy A Hirota, Stuart J Hirst, Mark D Inman, Wayne Mitzner, Tara E Sutherland

Research output: Contribution to journalArticlepeer-review

Abstract

Asthma is a complex disease that involves chronic inflammation and subsequent decline in airway function. The widespread use of animal models has greatly contributed to our understanding of the cellular and molecular pathways underlying human allergic asthma. Animal models of allergic asthma include smaller animal models which offer 'ease of use' and availability of reagents, and larger animal models that may be used to address aspects of allergic airways disease not possible in humans or smaller animal models. This review examines the application and suitability of various animal models for studying mechanisms of airway inflammation and tissue remodelling in allergic asthma, with a specific focus on airway smooth muscle.
Original languageEnglish
Pages (from-to)455-65
Number of pages11
JournalPulmonary Pharmacology and Therapeutics
Volume22
Issue number5
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Animals
  • Asthma
  • Disease Models, Animal
  • Gonadal Steroid Hormones
  • Humans
  • Immune System
  • Inflammation
  • Inflammation Mediators
  • Muscle, Smooth
  • Respiratory System
  • Sex Characteristics

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