Animal Models of Endometriosis: replicating the aetiology and symptoms of the human disorder.

Ioannis Simitsidellis; Douglas Gibson; Philippa Saunders

doi:10.1016/j.beem.2018.03.004

Animal Models of Endometriosis: replicating the aetiology and symptoms of the human disorder.

Ioannis Simitsidellis, Douglas Gibson, Philippa Saunders

Research output: Contribution to journal › Article › peer-review

Abstract

Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of models that recapitulate the key features of the disorder. In this review we describe the best-validated animal models (primate, rodent, xenograft) and their contributions to our understanding of the factors underpinning the development of symptoms. We consider the evidence that these models have provided the platform for identification of new therapeutic interventions and reflect on future directions for research and drug validation.

Original language	English
Journal	Best Practice and Research: Clinical Endocrinology and Metabolism
Early online date	6 Apr 2018
DOIs	https://doi.org/10.1016/j.beem.2018.03.004
Publication status	E-pub ahead of print - 6 Apr 2018

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abstract = "Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of models that recapitulate the key features of the disorder. In this review we describe the best-validated animal models (primate, rodent, xenograft) and their contributions to our understanding of the factors underpinning the development of symptoms. We consider the evidence that these models have provided the platform for identification of new therapeutic interventions and reflect on future directions for research and drug validation. ",

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Animal Models of Endometriosis: replicating the aetiology and symptoms of the human disorder.

Abstract

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