Aniridia, Wilms' tumor and human chromosome 11

W A Bickmore, N D Hastie

Research output: Contribution to journalArticlepeer-review

Abstract

Aniridia-a developmental abnormality of the eye in which the iris is apparently absent-has been shown to be genetically associated with Wilms' tumor (an embryonic nephroblastoma) in the WAGR syndrome. Genetic and cytogenetic evidence points to band p13 of human chromosome 11 as the localization of the genes responsible for these defects. Deleted chromosomes 11 from WAGR patients and clinically associated translocations involving 11p13 have been used to map and order genes and anonymous DNA markers around the WAGR locus refining the localization of the aniridia and Wilms' tumor genes to within about 1 million base pairs of DNA.

Original languageEnglish
Pages (from-to)229-48
Number of pages20
JournalOphthalmic paediatrics and genetics
Volume10
Issue number4
Publication statusPublished - Dec 1989

Keywords

  • Animals
  • Aniridia
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11
  • Cytogenetics
  • DNA, Neoplasm
  • Genetic Markers
  • Humans
  • Kidney Neoplasms
  • Mutation
  • Translocation, Genetic
  • Wilms Tumor

Fingerprint Dive into the research topics of 'Aniridia, Wilms' tumor and human chromosome 11'. Together they form a unique fingerprint.

Cite this