Abstract / Description of output
Neurocysticercosis (NC) presents a spectrum of clinical manifestations, with two broad clinical entities based on the central nervous system location of the parasite: extraparenchymal (EP-NC) and parenchymal (P-NC). In this work, using quantitative immunoblot methodology, we demonstrate the presence of autoantibodies to brain proteins in CSF from EP-NC, but not P-NC, patients. There was striking correlation between the level of autoantibodies and the levels of the secreted metacestode glycoprotein HP-10, suggesting that the level of stimulation of the autoantibody response may be a function of the number of viable parasites. Nine corresponding proteins autoantigens were provisionally identified by mass spectroscopy.
Original language | English |
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Pages (from-to) | 577234 |
Journal | Journal of Neuroimmunology |
Early online date | 6 Apr 2020 |
DOIs | |
Publication status | E-pub ahead of print - 6 Apr 2020 |
Keywords / Materials (for Non-textual outputs)
- Anti-brain autoantibodies
- autoantigens
- neurocysticercosis
- extraparenchymal
- parenchumal
- HP-10
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Institute for Genetics and Cancer Mass Spectrometry Facility
Alex Von Kriegsheim (Manager)
Deanery of Molecular, Genetic and Population Health SciencesFacility/equipment: Facility