Anti-brain protein autoantibodies are detectable in extraparenchymal but not parenchymal neurocysticercosis

R. Michael E. Parkhouse, Arturo Carpio, Maria Milagros Cortez, Alex Von Kriegsheim, Constantin Fesel

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Neurocysticercosis (NC) presents a spectrum of clinical manifestations, with two broad clinical entities based on the central nervous system location of the parasite: extraparenchymal (EP-NC) and parenchymal (P-NC). In this work, using quantitative immunoblot methodology, we demonstrate the presence of autoantibodies to brain proteins in CSF from EP-NC, but not P-NC, patients. There was striking correlation between the level of autoantibodies and the levels of the secreted metacestode glycoprotein HP-10, suggesting that the level of stimulation of the autoantibody response may be a function of the number of viable parasites. Nine corresponding proteins autoantigens were provisionally identified by mass spectroscopy.
Original languageEnglish
Pages (from-to)577234
JournalJournal of Neuroimmunology
Early online date6 Apr 2020
DOIs
Publication statusE-pub ahead of print - 6 Apr 2020

Keywords / Materials (for Non-textual outputs)

  • Anti-brain autoantibodies
  • autoantigens
  • neurocysticercosis
  • extraparenchymal
  • parenchumal
  • HP-10

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