Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells

O Gubbay, W Guo, M T Rae, D Niven, A F Howie, A S McNeilly, L Xu, S G Hillier

Research output: Contribution to journalArticlepeer-review


The majority of ovarian cancers (>90%) are believed to derive from the ovarian surface epithelium (OSE); a single layer covering the entire surface of the ovary. At ovulation, the OSE cell layer undergoes an inflammatory response, involving cell death and growth, in order to overcome ovarian surface rupture. Abnormalities during these processes are believed to contribute to the development of tumours. Using primary cultures of OSE cells, we have compared anti-inflammatory and proliferative responses directly between human and ovine OSE cells to further establish the use of ovine OSE cells as a suitable model system for the study of human OSE cells. In order to compare effects of inflammatory stimulation, expression and activity of 11betahydroxysteroid dehydrogenase (11betaHSD) type 1 was measured in OSE cells in response to interleukin (IL)-1alpha. As previously identified in human OSE cells, treatment of ovine OSE cells with IL-1alpha stimulated a concomitant increase of 11betaHSD type 1 mRNA (31-fold; P 1.2-fold (P 1.2-fold (P 1.5-fold (P
Original languageEnglish
Pages (from-to)607-14
Number of pages8
Issue number5
Publication statusPublished - 2004


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