Anti-Saccharomyces cerevisiae Antibodies Status Is Associated with Oral Involvement and Disease Severity in Crohn Disease

R. K. Russell, B. Ip, M. C. Aldhous, Margaret MacDougall, H. E. Drummond, I. D. R. Arnott, P. M. Gillett, P. McGrogan, L. T. Weaver, W. M. Bisset, G. Mahdi, D. C. Wilson, J. Satsangi

Research output: Contribution to journalArticlepeer-review


Objectives: To determine anti-Saccharomyces cerevisiae antibodies (ASCA) status and its relation to disease phenotype in patients with inflammatory bowel disease (IBD).

Patients and Methods: A total of 301 Scottish patients with early-onset IBD-197 Crohn disease (CD), 76 ulcerative colitis (UC), 28 indeterminate dolitis (IC)-and 78 healthy control individuals were studied. ASCA status (IgA, IgG) was determined by enzyme-linked immunosorbent assay. ASCA status was then analyzed in relation to CD phenotype.

Results: Patients with CD had a higher prevalence of ASCA than patients with UC and healthy controls: 82/197 versus 12/76, odds ratio (OR) 3.80 (1.93-7.50) and 82/197 versus 6/78, OR 8.56 (3.55-20.62), respectively. Univariate analysis showed that positive ASCA status was associated with oral CID (17/25 vs 59/153, OR 3.39 [1.38-8.34]), perianal CID (39/77 vs 38/108, OR 1.89 [1.04-3.44]) and the presence of granulomata (63/132 vs 15/52, OR 2.25 [1.13-4.48]) and also with markers of disease severity: raised C-reactive protein (44/90 vs 12/49, OR 2.95[1.36-6.37]), hypoalbuminemia (44/85 vs 20/74, OR 2.28[1.19-4.37]). and Surgery (27/49 vs 54/147, OR 2.11 [1.10-4.06]). From multivariate analysis, the presence of oral disease (adjusted P=0.001, OR 22.22 [3.41-142.86]) and hypoalbuminemia (adjusted P=0.01, OR 4.78 [1.40-16.39]) was found to be independently associated with ASCA status. No association was demonstrated between ASCA and IBD candidate genes.

Conclusions: Patients with CID had a higher prevalence of ASCA than did other patients with IBD. ASCA status described patients with CD who had a specific phenotype, showing an association with markers of disease severity and oral CD involvement. JPGN 48:161-167, 2009.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalJournal of pediatric gastroenterology and nutrition
Issue number2
Publication statusPublished - Feb 2009


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