Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses

Jennifer M Fitzpatrick, Emily Peak, Samirah Perally, Iain W Chalmers, John Barrett, Timothy P Yoshino, Alasdair C Ivens, Karl F Hoffmann

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Novel methods to identify anthelmintic drug and vaccine targets are urgently needed, especially for those parasite species currently being controlled by singular, often limited strategies. A clearer understanding of the transcriptional components underpinning helminth development will enable identification of exploitable molecules essential for successful parasite/host interactions. Towards this end, we present a combinatorial, bioinformatics-led approach, employing both statistical and network analyses of transcriptomic data, for identifying new immunoprophylactic and therapeutic lead targets to combat schistosomiasis.
Original languageEnglish
Article numbere543
JournalPLoS Neglected Tropical Diseases
Volume3
Issue number11
DOIs
Publication statusPublished - 2009

Keywords / Materials (for Non-textual outputs)

  • Schistosoma mansoni
  • Gene Expression Profiling
  • Animals
  • Schistosomiasis mansoni
  • Oligonucleotide Array Sequence Analysis
  • Humans
  • Helminth Proteins
  • Mice
  • Life Cycle Stages
  • Male
  • Gene Expression Regulation, Developmental
  • Female

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