Antibodies to the N-Terminal Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Associated with Protection against Clinical Malaria

D R Cavanagh, D Dodoo, L Hviid, J A L Kurtzhals, T G Theander, B D Akanmori, S Polley, D J Conway, K Koram, J S McBride, David Cavanagh

Research output: Contribution to journalArticlepeer-review

Abstract

This longitudinal prospective study shows that antibodies to the N-terminal block 2 region of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) are associated with protection against clinical malaria in an area of stable but seasonal malaria transmission of Ghana. Antibodies to the block 2 region of MSP-1 were measured in a cohort of 280 children before the beginning of the major malaria transmission season. The cohort was then actively monitored for malaria, clinically and parasitologically, over a period of 17 months. Evidence is presented for an association between antibody responses to block 2 and a significantly reduced risk of subsequent clinical malaria. Furthermore, statistical survival analysis provides new information on the duration of the effect over time. The results support a conclusion that the block 2 region of MSP-1 is a target of protective immunity against P. falciparum and, thus, a promising new candidate for the development of a malaria vaccine.

Original languageEnglish
Pages (from-to)6492-6502
Number of pages11
JournalInfection and Immunity
Volume72
Issue number11
DOIs
Publication statusPublished - Nov 2004

Keywords

  • MOLECULAR-WEIGHT PRECURSOR
  • IMMUNOGLOBULIN G3 SUBCLASS
  • HUMAN IMMUNE-RESPONSE
  • 19-KILODALTON DOMAIN
  • SERUM ANTIBODIES
  • ESCHERICHIA-COLI
  • ANTIGEN
  • FRAGMENT
  • AREA
  • HYPOTHESIS

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